Results 121 to 130 of about 202,754 (358)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Moderation and consistency of teacher judgement: teachers' views

, 2012
Major curriculum and assessment reforms in Australia have generated research interest in issues related to standards, teacher judgement and moderation.
Connelly, Stephen, Valentina Klenowski, Connolly, Stephen, Claire Maree Wyatt-Smith, Wyatt-Smith, Claire, Stephen Connolly, Klenowski, Valentina   +6 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Islamic Understanding in the Digital Age among University Student Associations

Millati: Journal of Islamic Studies and Humanities
The development of technology in the 4.0 era changes the order of human thought and performance to be faster, more efficient, and more effective in different sectors of life, one of which is in finding information.
Muhammad Khalilullah, Rian Vebrianto, Mahyudin Syukri , Iqbal Miftakhul Mujtahid, Dilva Hardila   +4 more
doaj   +1 more source

Moderating Effects of Cortisol on Neural-Cognitive Association in Cognitively Normal Elderly Subjects

Frontiers in Aging Neuroscience, 2017
Cortisol homeostasis is important for healthy brain and cognitive aging. The aim of the current study is to investigate the role of serum cortisol levels in the relationship between regional brain volumes and cognitive processing speed in a group of ...
Way K. W. Lau, Way K. W. Lau, Mei Kei Leung, Mei Kei Leung, Andrew C. K. Law, Andrew C. K. Law, Tatia M. C. Lee, Tatia M. C. Lee, Tatia M. C. Lee, Tatia M. C. Lee   +9 more
doaj   +1 more source

The Concept of Islamic Moderation in Indonesia: A Comparative Study in Tafsir An-Nur and Tafsir of the Ministry of Religious Affairs (MORA)

International Journal of Religion
This study aims to discuss Islamic moderation with a comparative study of Tafsir An-nur, and the Ministry of Religious Affairs (MORA). The method used in this study is qualitative with library research methods by looking for sources from written ...
Ahmad Nurrohim, A. Setiawan, Andri Arungga Sweta, Muthoifn   +3 more
semanticscholar   +1 more source

Teacher judgement and the challenges of moderation

, 2016
Moderation, or social moderation involves teachers meeting together to discuss and negotiate judgments made on student work. It is discussed in a holistic sense of encompassing all stages of the teaching/learning process. In systems that employ standards-
Klenowski, Val, Val Klenowski, Lenore Adie, Adie, Lenore   +3 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Great moderation at the firm level? Unconditional versus conditional output volatility [PDF]

Aggregated output in industrialized countries has become less volatile over the past decades. Whether this ?Great Moderation? can be found in firm level data as well remains disputed.
Buch, Claudia M., Stahn, Kerstin, Döpke, Jörg   +2 more
core  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source