Results 131 to 140 of about 241,852 (360)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Great moderation at the firm level? Unconditional versus conditional output volatility [PDF]

Aggregated output in industrialized countries has become less volatile over the past decades. Whether this ?Great Moderation? can be found in firm level data as well remains disputed.
Buch, Claudia M., Stahn, Kerstin, Döpke, Jörg   +2 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The great moderation in economic volatility: a view from the states [PDF]

Since the middle of the 1980s, economic growth in the U.S. has become much more stable than it was in the preceding three decades, and the magnitude of the decline is substantial.
Gerald A. Carlino
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

IMPLEMENTATION OF THE PAI LEARNING MODEL TO IMPROVE RELIGIOUS MODERATION AMONG IPB UNIVERSITY STUDENTS

Edukasi Islami: Jurnal Pendidikan Islam
This research aims to determine and analyse the implementation of the Islamic Religious Education (PAI) learning model to enhance religious moderation. The research was conducted at IPB University using a qualitative approach.
Muhammad Hidayat Ginanjar, Rahman Rahman, Arief Rahman Badrudin, Rifqi Hidayat   +3 more
doaj   +1 more source

Integration of Islamic Moderation Values in Islamic Education Curriculum as an Effort to Prevent Radicalism Early on

At-Thullab
This research aims to describe the integration of Islamic moderation values ​​in the Islamic Religious Education (PAI) curriculum at Madrasah Ibtidaiyah (MI) Bahrul Ulum Nataan Gedongboyo Untung Lamongan as an effort to prevent early radicalization.
Moch. Sya’roni Hasan, Solechan, Sunardi   +2 more
semanticscholar   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The "Great Moderation" and the US External Imbalance [PDF]

The early 1980s marked the onset of two striking features of the current world macro-economy: the fall in US business cycle volatility (the "great moderation") and the large and persistent US external imbalance.
Alessandra Fogli, Fabrizio Perri
core  

The spread of COVID-19 conspiracy theories on social media and the effect of content moderation

, 2020
We investigate the diffusion of conspiracy theories related to the origin of COVID-19 on social media. By analyzing third-party content on four social media platforms, we show that: (a) In contrast to conventional wisdom, mainstream sources contribute ...
Juan Carlos Medina Serrano, Papakyriakopoulos, Orestis;Medina Serrano, Juan Carlos;Hegelich, Simon, Simon Hegelich, Orestis Papakyriakopoulos   +3 more
core   +1 more source