Results 31 to 40 of about 565,191 (292)

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Can green finance policy promote ecosystem product value realization? Evidence from a quasi-natural experiment in China

Humanities & Social Sciences Communications
This study takes the Green Finance Pilot Zones (GFPZ) policy in China as a quasi-natural experiment and employs the synthetic control method to test the policy effect of GFPZ on ecosystem product value realization, using the province-level gross ...
Guoyong Wu, Jianwei Cheng, Fan Yang, Gaozhe Chen   +3 more
doaj   +1 more source

[Review of] Joseph Hraba. American Ethnicity [PDF]

, 1979
Hraba uses the social science disciplines--i.e., sociology, history, and psychology--to set the scope of his research on American ethnicity. Hraba combines the theoretical premises of assimilation, pluralism, and ethnic conflict theory as methods for ...
Hiura, Barbara
core   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Decoding Proton‐Coupled Electron Transfer Mechanism of Nicotine for Multi‐Scenario Portable Electrochemical Sensing

Advanced Science, EarlyView.
A key challenge in nicotine electroanalysis is the unresolved complexity of its interface process, which directly determines sensor metrics. Herein, the proton‐coupled electron transfer mechanism of nicotine is decoded for multi‐scenario portable electrochemical sensing.
Yi Peng, Qinyi Cao, Qianyu Shen, Yuhang Zhang, Shiyu Hu, Hongdou Yi, Qian Liu, Lihui Ou, Qiang Li, Zhaohong Su   +9 more
wiley   +1 more source

Zi Shen Wan Fang repaired blood–brain barrier integrity in diabetic cognitive impairment mice via preventing cerebrovascular cells senescence

Chinese Medicine
Background Blood–brain barrier (BBB) integrity disruption is a key pathological link of diabetes-induced cognitive impairment (DCI), but the detailed mechanism of how the diabetic environment induces BBB integrity disruption is not fully understood.
Qingsheng Yin, Genhui Yang, Runtao Su, Jie Bu, Ying Li, Han Zhang, Yanjun Zhang, Pengwei Zhuang   +7 more
doaj   +1 more source

Research on a Wind Turbine Gearbox Fault Diagnosis Method Using Singular Value Decomposition and Graph Fourier Transform

Sensors
Gearboxes operate in challenging environments, which leads to a heightened incidence of failures, and ambient noise further compromises the accuracy of fault diagnosis.
Lan Chen, Xiangfeng Zhang, Zhanxiang Li, Hong Jiang   +3 more
doaj   +1 more source

Discrimination of Free-Range and Caged Eggs by Chemometrics Analysis of the Elemental Profiles of Eggshell

Journal of Analytical Methods in Chemistry, 2023
As one of the foods commonly eaten all over the world, eggs have attracted more and more attention for their quality and price. A method based on elemental profiles and chemometrics to discriminate between free-range and caged eggs was established.
Shunping Xie, Chengying Hai, Song He, Huanhuan Lu, Lu Xu, Haiyan Fu   +5 more
doaj   +1 more source

The Modernization of Legal Lists [PDF]

, 1938
Worldwide, fatal traffic injuries and drowning deaths are important problems. The aim of this thesis was to investigate the cirumstances of fatal and non-fatal traffic injuries and drowning deaths in Sweden including analysis of the presence of alcohol ...
White, William R., Lawres, Irving A. J.
core   +1 more source

Impact of Discharging Methods on Electrode Integrity in Recycling of Lithium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Electrical and electrochemical discharge methods for end‐of‐life lithium‐ion batteries are compared. Electrochemical discharge better preserves the composition and layered structure of Ni‐rich cathode materials while minimizing residual lithium compounds.
Neha Garg, Viorica‐Alina Oltean, Daniel Brandell, Annukka Santasalo Aarnio   +3 more
wiley   +1 more source