Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
Molecules, 2023 Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant Sophora flavescens using an organic solvent.
Zhizhong Wang
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Dietary Matrine Supplementation Enhances Growth, Immunity and Disease Resistance in Nile Tilapia (Oreochromis niloticus) [PDF]
AnimalsMatrine, a bioactive alkaloid from Sophora flavescens, has gained attention as a phytogenic additive due to its antioxidant and immunomodulatory properties.
Siyu Luo +11 more
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Frontiers in Chemistry, 2022 Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora flavescentis, Sophora alopecuroides, Sophora root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs. It exhibits distinct benefits in preventing and improving chronic diseases such as cardiovascular disease and tumors.
Cao Hui-Ling, Sun Xiao-Ying
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Safety evaluation of matrine and its impact as a feed additive on the production performance of piglets [PDF]
Frontiers in Veterinary ScienceIntroductionPrevious studies have suggested that matrine may improve animal production performance, but its role and underlying mechanisms remain unclear.MethodsFollowing the determination of the LD50 of matrine in ICR mice, the long-term toxic effects ...
Zhigang Cao +14 more
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Integrated metabolomics and gut microbiota analyses reveal the protective effects of matrine in ulcerative colitis [PDF]
Frontiers in ChemistryBackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease driven by gut microbial dysbiosis and metabolic dysfunction. Matrine, a natural alkaloid with anti-inflammatory properties, shows therapeutic potential; however, its mechanisms ...
Linqi Su +10 more
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Lanzhou Lily (<i>Lilium davidii var. unicolor</i>) Extract Alleviates Chronic Stress-Induced Mood Disturbances by Suppressing Neuroinflammation and Modulating the Gut-Brain Axis in Mice. [PDF]
Food Sci NutrLanzhou lily extract (LLE) alleviates chronic restraint stress–induced mood disturbances by reducing central inflammation, improving intestinal barrier integrity, attenuating systemic inflammation, and ultimately restoring gut–brain axis homeostasis in mice.
An Z +7 more
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Cell Death and Disease, 2021 Studies have shown that matrine has antitumor activity against many types of cancers. However, the direct target in cancer cells of its anticancer effect has not been identified.
Xi Zhang +7 more
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Frontiers in Pharmacology, 2022 Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear.
Wang-Jing Zhong +6 more
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Total Synthesis of Matrine Alkaloids
Journal of the American Chemical Society, 2022 The total synthesis of three diastereomeric matrine natural products is reported. The eight-step synthesis commences with simple acyclic precursors, forms all four rings of the tetracyclic natural product framework and forges ten of the twenty covalent bonds of the target structure.
Nicholas L. Magann +4 more
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Molecular Rotation Spectrum of Tetracyclic Quinolizidines: Observation of trans-Matrine and the Elusive cis-Matrine [PDF]
The Journal of Organic Chemistry, 2021 We characterized the bis-quinolizidine tetracyclic alkaloid (5S, 6S, 7R, 11R)-matrine in a supersonic jet expansion, using chirped-pulsed broadband microwave spectroscopy. Previous crystal diffraction analyses suggested 16 diastereoisomers associated with matrine's four carbon stereocenters but were inconclusive whether the lactamic nitrogen atom would
Juanes San José, Marcos +4 more
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