Results 1 to 10 of about 4,760 (206)

Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives

Molecules, 2023
Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant Sophora flavescens using an organic solvent.
Jinlei Li, Shijie Wei, Davies Marabada, Zhizhong Wang, Qing Huang   +4 more
exaly   +6 more sources

Synthesis of Halopyrazole Matrine Derivatives and Their Insecticidal and Fungicidal Activities

Molecules, 2022
Matrine is a traditional botanical pesticide with a broad-spectrum biological activity that is widely applied in agriculture. Halopyrazole groups are successfully introduced to the C13 of matrine to synthesize eight new derivatives with a yield of 78–87%.
Chunbao Charles Xu, Xiangjing Qin, Xingan Cheng   +2 more
exaly   +4 more sources

Mechanism of matrine inhibiting retinoblastoma cell growth by downregulating NR1D2 to regulate phosphorylation of the PI3K/AKT signaling pathway [PDF]

Scientific Reports
This study explored the mechanism of matrine-induced apoptosis in human retinoblastoma (RB) cell. Network pharmacology and proteomics approaches were employed to screen the intersection between the pharmacodynamic targets of matrine and the pathogenic ...
Li Kong, Yangrui Du, Xiaomei Lan, Qian Zheng, Qingqing Hu, Tao Li, Li Bin, Zhiyu Du   +7 more
doaj   +2 more sources

Dietary Matrine Supplementation Enhances Growth, Immunity and Disease Resistance in Nile Tilapia (Oreochromis niloticus) [PDF]

Animals
Matrine, a bioactive alkaloid from Sophora flavescens, has gained attention as a phytogenic additive due to its antioxidant and immunomodulatory properties.
Siyu Luo, Yue Liang, Chao Wang, Yifan Zhai, Xinyi Guo, Shupeng Zhang, Erlei Zhang, Dengfeng Yang, Du Guo, Tianqiang Liu, Gaoxue Wang, Erlong Wang   +11 more
doaj   +2 more sources

Integrated metabolomics and gut microbiota analyses reveal the protective effects of matrine in ulcerative colitis [PDF]

Frontiers in Chemistry
BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease driven by gut microbial dysbiosis and metabolic dysfunction. Matrine, a natural alkaloid with anti-inflammatory properties, shows therapeutic potential; however, its mechanisms ...
Linqi Su, Linqi Su, Yu Zhang, Yixuan Xie, Jiazhen Wu, Yang Yang, Yun Li, Yongtong Huang, Xin Liu, Xuemei Wei, Qinhua Chen   +10 more
doaj   +2 more sources

Matrine as a multi-disease regulator of ferroptosis: mechanisms, therapeutic applications, and toxicity management [PDF]

Frontiers in Pharmacology
Matrine is the main active metabolite of Sophora flavescens Ait. Matrine is a traditional medicine with a long history of medicinal use. Modern pharmacological research confirms that matrine possesses a variety of pharmacological effects, including anti ...
Yuhan Lu, Jianrong Ye
doaj   +2 more sources

Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways

Cell Death and Disease, 2021
Studies have shown that matrine has antitumor activity against many types of cancers. However, the direct target in cancer cells of its anticancer effect has not been identified.
Xi Zhang, Hui Xu, Xiaoyang Bi, Guoqing Hou, Andong Liu, Youyun Zhao, Guoping Wang, Xuan Cao   +7 more
doaj   +1 more source

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Frontiers in Pharmacology, 2022
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear.
Wang-Jing Zhong, Lingdi Ma, Lingdi Ma, Fanfan Yang, Jialin Cao, Junyu Tan, Bohong Li   +6 more
doaj   +1 more source

Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production

Frontiers in Pharmacology, 2021
Matrine is a naturally occurring alkaloid and possesses a wide range of pharmacological properties, such as anti-cancer, anti-oxidant, anti-inflammatory effects. However, whether it affects platelet function and thrombosis remains unclear.
Sixuan Zhang, Sixuan Zhang, Sixuan Zhang, Xiang Gui, Xiang Gui, Xiang Gui, Yangyang Ding, Yangyang Ding, Yangyang Ding, Huan Tong, Huan Tong, Huan Tong, Wen Ju, Wen Ju, Wen Ju, Yue Li, Zhenyu Li, Zhenyu Li, Zhenyu Li, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Kailin Xu, Kailin Xu, Kailin Xu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao   +28 more
doaj   +1 more source

Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study.

PLoS ONE, 2023
Matrine, an alkaloid derived from herbal medicine, has a wide range of biological activities, including antibacterial. Matrine was toxic to multiple cells at high concentrations.
Zhao Zhang, Yuze Yang, Lijiao Yan, Xuerui Wan, Kangyongjie Sun, Huitian Gou, Jucai Ding, Jie Peng, Guo Liu, Chuan Wang   +9 more
doaj   +1 more source