Results 41 to 50 of about 3,599 (178)

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Synthesis of Halopyrazole Matrine Derivatives and Their Insecticidal and Fungicidal Activities

Molecules, 2022
Matrine is a traditional botanical pesticide with a broad-spectrum biological activity that is widely applied in agriculture. Halopyrazole groups are successfully introduced to the C13 of matrine to synthesize eight new derivatives with a yield of 78–87%.
Xingan Cheng, Huiqing He, Fangyun Dong, Chunbao Charles Xu, Hanhui Zhang, Zhanmei Liu, Xiaojing Lv, Yuehua Wu, Xuhong Jiang, Xiangjing Qin   +9 more
doaj   +1 more source

The Pharmacological Studies on Matrine and Oxymatrine

YAKUGAKU ZASSHI, 2000
Matrine and oxymatrine, major components of Sophora flavescens, were confirmed to have a protective effect on restraint and water immersion stress ulcer in mice. Oxymatrine inhibits the formation of some experimental gastric ulcer, pylorus ligation ulcer and indomethacin ulcer, which are considered to relate to acid secretion. Oxymatrine decreases acid
openaire   +3 more sources

Advances in Research on the Anti‐Tuberculosis Effects of Active Components in Chinese Herbal Medicine

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
This review summarizes how active constituents derived from Chinese herbal medicine exert anti‐tuberculosis (TB) effects via immunomodulation, direct inhibition of pathogens, and antioxidant activity. This synergistic, multi‐pathway mechanism highlights their potential as promising therapeutic candidates and adjunctive treatments against drug‐resistant
Qianqian Zhang, Siqi Lin, Juan Liu, Huani Wu, Xiaodan Lin, Jiawen He, Qiaoyu Yang, Jiang Pi, Fen Yang   +8 more
wiley   +1 more source

Matrine alkaloids modulating DNA damage repair in chemoresistant non-small cell lung cancer cells

BMC Cancer
Background Non-small cell lung cancer (NSCLC) presents a significant challenge in the medical field due to its high incidence and resistance to chemotherapy. Chemoresistance in NSCLC diminishes treatment efficacy and contributes to poor patient outcomes.
Fengping Wang, Jun Liu, Wenliang Liao, Lixiang Zheng, Shuai Qian, Lisi Mao   +5 more
doaj   +1 more source

Isolation and identification of a matrine-producing fungal strain from petroleum-contaminated soil

浙江大学学报. 农业与生命科学版, 2015
Matrine is one of the quinolizidine alkaloids. It is widely used as broad-spectrum agricultural pesticides, which exists mainly in roots of leguminous plants.
Mao Dongxia, Guo Dandan, Wu Lingling, Tian Xiaoxue, Zhang Shengxiang, Liu Tao, Ma Xiaokui   +6 more
doaj   +1 more source

Effect of matrine on proliferation and migration of human thyroid cancer cell line TPC-1 [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the mechanism of matrine inhibiting the proliferation and migration of thyroid cancer cell line TPC-1 through down-regulated miRNA-182-5p TPC-1. Methods TPC-1 cells were transfected after 24 hours with 0.5 mg/mL matrine or
FU Song-bo, MA Cheng-xu, JING Gao-jing, ZHAO Nan, TANG Xu-lei, MOU Jun-qin, CHANG Yin-long
doaj  

Phytotherapeutic Regulation of Matrix Metalloproteinases in Diabetic Foot Ulcer: Molecular Mechanisms and Wound Healing Perspectives

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Chronic inflammation in diabetic foot ulcers elevates MMP activity and suppresses TIMP and growth factor signaling, impairing tissue repair. Phytochemicals modulate NF‐κB/MAPK pathways and enhance Nrf2–TIMP expression, restoring MMP/TIMP balance, promoting collagen deposition, angiogenesis, and re‐epithelialization, leading to effective wound healing ...
Vishnu Priyan Elaiyaraja, Eswara Rajagopal, Subhikssha Babu, Balaji Sadhasivam   +3 more
wiley   +1 more source

Migration, colonization and seedling growth of rhizobia with matrine treatment in alfalfa (Medicago sativa L.)

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2018
Purpose: The purposes of this study were to determine the effect of matrine on the migration and the colonization dynamics of the two fluorescent-tagged rhizobia in Gannong No.5 alfalfa (Medicago sativa L. Gannong No.
Yang-yang Miao, Shang-li Shi, Jian-guo Zhang, Osama Abdalla Mohamad   +3 more
doaj   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, Volume 40, Issue 6, Page 3171-3189, June 2026.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source