Results 41 to 50 of about 4,760 (206)

Safety evaluation of matrine and its impact as a feed additive on the production performance of piglets

Frontiers in Veterinary Science
IntroductionPrevious studies have suggested that matrine may improve animal production performance, but its role and underlying mechanisms remain unclear.MethodsFollowing the determination of the LD50 of matrine in ICR mice, the long-term toxic effects ...
Zhigang Cao, Yalin Wu, Xiangming Cong, Abdul Haseeb, Panpan Sun, Hua Zhang, Kuohai Fan, Wei Yin, Huizhen Yang, Zhenbiao Zhang, Jia Zhong, Jianzhong Wang, Yaogui Sun, Hongquan Li, Na Sun   +14 more
doaj   +1 more source

Sedative Effect ofSophora flavescensand Matrine [PDF]

Biomolecules & Therapeutics, 2017
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by assessing c-Fos immunoreactivity and serotonin (5-HT) in the
Lee, Hyun-ju, Lee, Sun-young, Jang, Daehyuk, Chung, Sun-Yong, Shim, Insop   +4 more
openaire   +2 more sources

Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome

Veterinary Research, 2019
Our previous studies demonstrated that matrine directly acts on the replication process of porcine reproductive and respiratory syndrome virus (PRRSV). Matrine inhibits viral replication and is also associated with the NF-κB signalling pathway.
Panpan Sun, Na Sun, Wei Yin, Yaogui Sun, Kuohai Fan, Jianhua Guo, Ajab Khan, Yongming He, Hongquan Li   +8 more
doaj   +1 more source

Formulation of Matrine Oil-Based Suspension Concentrate for Improving the Wetting of Droplets and Spraying Performance

Agronomy, 2023
Matrine is an efficient, low-toxicity, and environmentally friendly botanical pesticide; however, it is mainly applied as a soluble concentrate (SL) with a limited utilization rate that is unsuitable for ultra-low-volume spraying and unmanned aerial ...
Meng Li, Zhen Wang, Huanwen Meng, Baozhu Dong, Xile Deng, Hongyou Zhou   +5 more
doaj   +1 more source

UPLC‐Q‐TOF‐MS/MS Profiling and Synergistic Anti‐HCC Activity of Gallic Acid From Compound Muji Granules Combined With hUC‐MSC‐Exos [PDF]

Chem Biodivers
Human‐umbilical‐cord‐mesenchymal‐stem‐cell‐derived exosomes amplify anti‐hepatocellular‐carcinoma effects of gallic acid from Compound Muji Granules. This work identifies absorbed herbal constituents and reveals modulation of IL‐17/MAPK/p53 signaling in HCC organoid models, offering mechanistic insights for exosome‐assisted traditional‐medicine ...
Zhang Q, Wang Y, Huo J, Han L, Meng Y, Li Y, Shi J, Wu X, Bao Y, Wang S, Li T, Leng J, Meng X.   +12 more
europepmc   +2 more sources

Electrochemical Behavior and Determination of Matrine by the Reduced Graphene Oxide-Nafion Modified Glassy Carbon Electrode

International Journal of Electrochemical Science, 2015
Reduced graphene oxide-Nafion composite modified glassy carbon electrode (RGO-Nafion/GCE) was prepared and the electrochemical behavior of matrine at RGO-Nafion/GCE was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV).
Hongjiao Zhang, Huabin Xiong, Yuntao Gao, Zhengwei Wang, Xiaofen Li, Xiaoyan Ma, Hongqiao Yang   +6 more
doaj   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Matrin 3 Binds and Stabilizes mRNA

PLoS ONE, 2011
Matrin 3 (MATR3) is a highly conserved, inner nuclear matrix protein with two zinc finger domains and two RNA recognition motifs (RRM), whose function is largely unknown. Recently we found MATR3 to be phosphorylated by the protein kinase ATM, which activates the cellular response to double strand breaks in the DNA. Here, we show that MATR3 interacts in
Salton, M., Elkon, R., Borodina, T., Davydov, A., Yaspo, M., Halperin, E., Shiloh, Y.   +6 more
openaire   +5 more sources

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Photos of matrine against H9N2 in vitro when cytopathic of viral control was +++.

, 2013
A. Blank control, B. Viral control, C. 0.4 mg/ml matrine, D. 0.2 mg/ml matrine, E. 0.1 mg/ml matrine.
Jian-Yong Li (424635), Ya-Jun Yang (119016), Ji-Yu Zhang (5007728), Bing Li (43671), Yu-Rong Liu (502012), Xi-Wang Liu (502011)   +5 more
core   +1 more source