Results 21 to 30 of about 4,598 (207)

Mechanism of matrine inhibiting retinoblastoma cell growth by downregulating NR1D2 to regulate phosphorylation of the PI3K/AKT signaling pathway. [PDF]

Sci Rep
This study explored the mechanism of matrine-induced apoptosis in human retinoblastoma (RB) cell. Network pharmacology and proteomics approaches were employed to screen the intersection between the pharmacodynamic targets of matrine and the pathogenic ...
Kong L, Du Y, Lan X, Zheng Q, Hu Q, Li T, Bin L, Du Z.   +7 more
europepmc   +2 more sources

Effect of matrine on proliferation and migration of human thyroid cancer cell line TPC-1 [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the mechanism of matrine inhibiting the proliferation and migration of thyroid cancer cell line TPC-1 through down-regulated miRNA-182-5p TPC-1. Methods TPC-1 cells were transfected after 24 hours with 0.5 mg/mL matrine or
FU Song-bo, MA Cheng-xu, JING Gao-jing, ZHAO Nan, TANG Xu-lei, MOU Jun-qin, CHANG Yin-long
doaj   +1 more source

Dietary Matrine Supplementation Enhances Growth, Immunity and Disease Resistance in Nile Tilapia (<i>Oreochromis niloticus</i>). [PDF]

Animals (Basel)
Matrine, a bioactive alkaloid from Sophora flavescens, has gained attention as a phytogenic additive due to its antioxidant and immunomodulatory properties.
Luo S, Liang Y, Wang C, Zhai Y, Guo X, Zhang S, Zhang E, Yang D, Guo D, Liu T, Wang G, Wang E.   +11 more
europepmc   +2 more sources

A Pyridine Dearomatization Approach to the Matrine-type Lupin Alkaloids [PDF]

, 2022
(+)-Matrine and (+)-isomatrine are tetracyclic alkaloids isolated from the plant Sophora flavescens, the roots of which are used in traditional Chinese medicine.
Pik Hoi, Lam, Kendall, Houk, Andrea, Stegner, Aneta, Turlik, Jeffrey, Kerkovius, Sarah, Reisman   +5 more
core   +2 more sources

Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways

Cell Death and Disease, 2021
Studies have shown that matrine has antitumor activity against many types of cancers. However, the direct target in cancer cells of its anticancer effect has not been identified.
Xi Zhang, Hui Xu, Xiaoyang Bi, Guoqing Hou, Andong Liu, Youyun Zhao, Guoping Wang, Xuan Cao   +7 more
doaj   +1 more source

Integrated metabolomics and gut microbiota analyses reveal the protective effects of matrine in ulcerative colitis. [PDF]

Front Chem
BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease driven by gut microbial dysbiosis and metabolic dysfunction. Matrine, a natural alkaloid with anti-inflammatory properties, shows therapeutic potential; however, its mechanisms ...
Su L, Zhang Y, Xie Y, Wu J, Yang Y, Li Y, Huang Y, Liu X, Wei X, Chen Q.   +9 more
europepmc   +2 more sources

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Frontiers in Pharmacology, 2022
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear.
Wang-Jing Zhong, Lingdi Ma, Lingdi Ma, Fanfan Yang, Jialin Cao, Junyu Tan, Bohong Li   +6 more
doaj   +1 more source

Safety evaluation of matrine and its impact as a feed additive on the production performance of piglets. [PDF]

Front Vet Sci
IntroductionPrevious studies have suggested that matrine may improve animal production performance, but its role and underlying mechanisms remain unclear.MethodsFollowing the determination of the LD50 of matrine in ICR mice, the long-term toxic effects ...
Cao Z, Wu Y, Cong X, Haseeb A, Sun P, Zhang H, Fan K, Yin W, Yang H, Zhang Z, Zhong J, Wang J, Sun Y, Li H, Sun N.   +14 more
europepmc   +2 more sources

Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production

Frontiers in Pharmacology, 2021
Matrine is a naturally occurring alkaloid and possesses a wide range of pharmacological properties, such as anti-cancer, anti-oxidant, anti-inflammatory effects. However, whether it affects platelet function and thrombosis remains unclear.
Sixuan Zhang, Sixuan Zhang, Sixuan Zhang, Xiang Gui, Xiang Gui, Xiang Gui, Yangyang Ding, Yangyang Ding, Yangyang Ding, Huan Tong, Huan Tong, Huan Tong, Wen Ju, Wen Ju, Wen Ju, Yue Li, Zhenyu Li, Zhenyu Li, Zhenyu Li, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Kailin Xu, Kailin Xu, Kailin Xu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao   +28 more
doaj   +1 more source

Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study.

PLoS ONE, 2023
Matrine, an alkaloid derived from herbal medicine, has a wide range of biological activities, including antibacterial. Matrine was toxic to multiple cells at high concentrations.
Zhao Zhang, Yuze Yang, Lijiao Yan, Xuerui Wan, Kangyongjie Sun, Huitian Gou, Jucai Ding, Jie Peng, Guo Liu, Chuan Wang   +9 more
doaj   +1 more source