Results 21 to 30 of about 4,760 (206)
Synthesis and Evaluation of 11-Butyl Matrine Derivatives as Potential Anti-Virus Agents
Molecules, 2022 Matrine derivatives were reported to have various biological activities, especially the ester, amide or sulfonamide derivatives of matrine deriving from the hydroxyl or carboxyl group at the end of the branch chain after the D ring of matrine is opened ...
Wanjun Ni +4 more
doaj +2 more sources
Matrine Inhibits Mouse Sperm Function by Reducing Sperm [Ca2+]i and Phospho-ERK1/2
Cellular Physiology and Biochemistry, 2015 Background: Matrine is a bioactive alkaloid that has a variety of pharmacological effects and is widely used in Chinese medicine. However, its effects on male reproduction are not well known.
Tao Luo +5 more
doaj +2 more sources
Matrine Mediates Inflammatory Response via Gut Microbiota in TNBS-Induced Murine Colitis [PDF]
Frontiers in Physiology, 2019 This study mainly investigated the effect of matrine on TNBS-induced intestinal inflammation in mice. TNBS treatment caused colonic injury and gut inflammation.
Peiyuan Li +5 more
doaj +2 more sources
Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling. [PDF]
Thorac CancerMatrine simultaneously targets CHEK1 (impairing DNA repair, increasing γH2AX) and PI3K/AKT (activating mitochondrial apoptosis), reduced EMT, and strong in vitro and in vivo antitumor effects with low toxicity, positioning it as a promising dual‐mechanism agent for lung cancer.
Yu J +12 more
europepmc +2 more sources
A Pyridine Dearomatization Approach to the Matrine-type Lupin Alkaloids [PDF]
, 2022 (+)-Matrine and (+)-isomatrine are tetracyclic alkaloids isolated from the plant Sophora flavescens, the roots of which are used in traditional Chinese medicine.
Pik Hoi, Lam +17 more
core +3 more sources
Frontiers in Chemistry, 2022 Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora flavescentis, Sophora alopecuroides, Sophora root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs. It exhibits distinct benefits in preventing and improving chronic diseases such as cardiovascular disease and tumors.
Xiao-Ying Sun +20 more
openaire +3 more sources
BMC Complementary Medicine and Therapies, 2021 Background C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from Sophora flavescens Ait.
Jianyou Gu +8 more
doaj +1 more source
BMC Complementary Medicine and Therapies, 2020 Background C-Myc overexpression is associated with poor prognosis and aggressive progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid of the traditional Chinese herb Sophora flavescens Ait, has been shown to inhibit cellular ...
Jianyou Gu +10 more
doaj +1 more source
, 2018 Eight new matrine-type alkaloids, flavesines G–J (1–4), alopecurine B (5), 7,11-dehydro-oxymatrine (6), 10-oxy-5,6-dehydromatrine (7), and 10-oxysophoridine (8), along with nine known analogues (9–17) were isolated from the roots of Sophora flavescens ...
Wen Cheng (134453) +8 more
core +2 more sources
Pharmaceutical Biology, 2020 Context Matrine is a well-known anti-inflammatory quinolizidine alkaloid derived from leguminous plant Sophora flavescens Ait. (Leguminosae). Objective This study was designed to uncover the potential application of matrine in treating spinal cord injury
Jinsong Jiang, Guangji Wang
doaj +1 more source