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Matrine as a multi-disease regulator of ferroptosis: mechanisms, therapeutic applications, and toxicity management. [PDF]
Front PharmacolMatrine is the main active metabolite of Sophora flavescens Ait. Matrine is a traditional medicine with a long history of medicinal use. Modern pharmacological research confirms that matrine possesses a variety of pharmacological effects, including anti ...
Lu Y, Ye J.
europepmc +2 more sources
Frontiers in Physiology, 2021 Matrine, an active component of Sophora flavescens Ait root extracts, has been used in China for years to treat cancer and viral hepatitis. In the present study, we explored the effects of matrine on hyperglycemia-treated cardiomyocytes.
Tong Xiao +4 more
doaj +1 more source
BMC Complementary Medicine and Therapies, 2020 Background C-Myc overexpression is associated with poor prognosis and aggressive progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid of the traditional Chinese herb Sophora flavescens Ait, has been shown to inhibit cellular ...
Jianyou Gu +10 more
doaj +1 more source
BMC Complementary Medicine and Therapies, 2021 Background C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from Sophora flavescens Ait.
Jianyou Gu +8 more
doaj +1 more source
As a continuation of our research on the development of pesticide active quinolizidine alkaloids (QAs) from the family Fabaceae, the chemical constituents of the root of Sophora tonkinensis Gagnep. were systematically investigated.
Juan Wang (115708) +9 more
core +4 more sources
Frontiers in Pharmacology, 2018 After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate.
Norio Tanabe +2 more
doaj +1 more source
, 2018 Eight new matrine-type alkaloids, flavesines G–J (1–4), alopecurine B (5), 7,11-dehydro-oxymatrine (6), 10-oxy-5,6-dehydromatrine (7), and 10-oxysophoridine (8), along with nine known analogues (9–17) were isolated from the roots of Sophora flavescens ...
Wen Cheng (134453) +8 more
core +2 more sources
Pharmaceutical Biology, 2020 Context Matrine is a well-known anti-inflammatory quinolizidine alkaloid derived from leguminous plant Sophora flavescens Ait. (Leguminosae). Objective This study was designed to uncover the potential application of matrine in treating spinal cord injury
Jinsong Jiang, Guangji Wang
doaj +1 more source
Research progress on the pharmacological effects of matrine
Frontiers in Neuroscience, 2022 Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth; (2) reduction of oxidized low-density lipoprotein and ...
Yanan Sun +8 more
openaire +3 more sources
BMC Genomics, 2022 Background Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae) is a serious pest of crops in different regions of the world. Our recent studies on the joint application of Akanthomyces attenuatus (a pathogenic insect fungus) and matrine (a botanical ...
Jianhui Wu +5 more
doaj +1 more source