Results 11 to 20 of about 3,599 (178)

Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production

Frontiers in Pharmacology, 2021
Matrine is a naturally occurring alkaloid and possesses a wide range of pharmacological properties, such as anti-cancer, anti-oxidant, anti-inflammatory effects. However, whether it affects platelet function and thrombosis remains unclear.
Sixuan Zhang, Sixuan Zhang, Sixuan Zhang, Xiang Gui, Xiang Gui, Xiang Gui, Yangyang Ding, Yangyang Ding, Yangyang Ding, Huan Tong, Huan Tong, Huan Tong, Wen Ju, Wen Ju, Wen Ju, Yue Li, Zhenyu Li, Zhenyu Li, Zhenyu Li, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Kailin Xu, Kailin Xu, Kailin Xu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao   +28 more
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Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study.

PLoS ONE, 2023
Matrine, an alkaloid derived from herbal medicine, has a wide range of biological activities, including antibacterial. Matrine was toxic to multiple cells at high concentrations.
Zhao Zhang, Yuze Yang, Lijiao Yan, Xuerui Wan, Kangyongjie Sun, Huitian Gou, Jucai Ding, Jie Peng, Guo Liu, Chuan Wang   +9 more
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Matrine inhibits the growth of natural killer/T-cell lymphoma cells by modulating CaMKIIγ-c-Myc signaling pathway

BMC Complementary Medicine and Therapies, 2020
Background C-Myc overexpression is associated with poor prognosis and aggressive progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid of the traditional Chinese herb Sophora flavescens Ait, has been shown to inhibit cellular ...
Jianyou Gu, Yu Zhang, Xiao Wang, Jingjing Xiang, Shu Deng, Dijiong Wu, Junfa Chen, Lihong Yu, Yan Zhou, Yaokun Wang, Jianping Shen   +10 more
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Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway

BMC Complementary Medicine and Therapies, 2021
Background C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from Sophora flavescens Ait.
Jianyou Gu, Xiao Wang, Ling Zhang, Jingjing Xiang, Jingya Li, Zheng Chen, Yu Zhang, Junfa Chen, Jianping Shen   +8 more
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RETRACTED: Matrine Protects Cardiomyocytes Against Hyperglycemic Stress by Promoting Mitofusin 2-Induced Mitochondrial Fusion

Frontiers in Physiology, 2021
Matrine, an active component of Sophora flavescens Ait root extracts, has been used in China for years to treat cancer and viral hepatitis. In the present study, we explored the effects of matrine on hyperglycemia-treated cardiomyocytes.
Tong Xiao, Jie Huang, Yuan Liu, Yujie Zhao, Manman Wei   +4 more
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Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Hepatocellular carcinoma (HCC) is a complex issue in cancer treatment in the world at present. Matrine is the main active ingredient isolated from Sophora flavescens air and possesses excellent antitumor effects in HCC.
Kexin Wang, Kexin Wang, Kexin Wang, Xiangmin Ye, Chuanhui Yin, Qing Ren, Qing Ren, Yupeng Chen, Xuemei Qin, Chuanzhi Duan, Aiping Lu, Li Gao, Daogang Guan, Daogang Guan   +13 more
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Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice

Frontiers in Pharmacology, 2018
After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate.
Norio Tanabe, Tomoharu Kuboyama, Chihiro Tohda   +2 more
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Matrine protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via upregulation of miR-9

Pharmaceutical Biology, 2020
Context Matrine is a well-known anti-inflammatory quinolizidine alkaloid derived from leguminous plant Sophora flavescens Ait. (Leguminosae). Objective This study was designed to uncover the potential application of matrine in treating spinal cord injury
Jinsong Jiang, Guangji Wang
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Matrine suppresses KRAS‐driven pancreatic cancer growth by inhibiting autophagy‐mediated energy metabolism

Molecular Oncology, 2018
Matrine is a natural compound extracted from the herb Sophora flavescens Ait which is widely used in traditional Chinese medicine for treating various diseases. Recently, matrine was reported to have antitumor effects against a variety of cancers without
Young‐ra Cho, Ji Hyeon Lee, Ji Hye Kim, So‐Yeon Lee, Suna Yoo, Min‐kyo Jung, Su Jung Kim, Hyun Ju Yoo, Chang‐Gi Pack, Jin Kyung Rho, Jaekyoung Son   +10 more
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Research progress on the pharmacological effects of matrine

Frontiers in Neuroscience, 2022
Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth; (2) reduction of oxidized low-density lipoprotein and ...
Yanan Sun, Lu Xu, Qihan Cai, Mengmeng Wang, Xinliang Wang, Siming Wang, Zhiyu Ni, Zhiyu Ni, Zhiyu Ni   +8 more
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