Results 41 to 50 of about 42,970 (168)

Elephant Cathelicidin-Derived Peptides Inhibit Herpes Simplex Virus 1 Infection

Antibiotics
Herpes simplex virus type 1 (HSV-1) is a globally prevalent pathogen that can infect a variety of animal species as well as humans. However, existing antiviral therapies are constrained in their capacity to effectively target viral latency and prevent ...
Haiche Yisihaer, Peng Dong, Pengpeng Li, Enjie Deng, Rui Meng, Lin Jin, Guilan Li   +6 more
doaj   +1 more source

Simultaneous Quantification of Multiple Analytes in Rat Plasma by UHPLC–MS/MS Following Oral Administration of Gastrodiae Rhizoma Extract for Pharmacokinetic Evaluation

Molecules
Gastrodiae Rhizoma (GR) is known to have a medicinal and food-based homology. It is used to treat infantile convulsion, epilepsy, spasm, tetanus, and vertigo.
Lu Chen, Yameng Zhu, Huizi Ouyang, Xiwei Wu, Wenhan Lin, Kaili Zhang, Jun He   +6 more
doaj   +1 more source

TRAINING TECHNOLOGIES IN THE EDUCATION OF LYCEUM STUDENTS (ON THE EXAMPLE OF LYCEUMS OF SECURITY AND NATIONAL PATRIOTIC EDUCATION OF THE MINISTRY OF INTERNAL AFFAIRS OF UKRAINE)

Неперервна професійна освіта: теорія та практика
The article highlights the specifics of the activities of security-oriented lyceums and national-patriotic education within the Ministry of Internal Affairs of Ukraine.
Ievgen Bazhenkov , Halyna Kolomoiets , Natalia Divinska   +2 more
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A Cyclic Peptide Based on Pheasant Cathelicidin Inhibits Influenza A H1N1 Virus Infection

Antibiotics
Influenza viruses are the leading cause of upper respiratory tract infections, leading to several global pandemics and threats to public health. Due to the continuous mutation of influenza A viruses, there is a constant need for the development of novel ...
Yaping Pei, Zhihua Chen, Ruihan Zhao, Yanxing An, Haiche Yisihaer, Chaojie Wang, Yaning Bai, Libin Liang, Lin Jin, Yongting Hu   +9 more
doaj   +1 more source

Drug–target interaction prediction by integrating heterogeneous information with mutual attention network

BMC Bioinformatics
Background Identification of drug–target interactions is an indispensable part of drug discovery. While conventional shallow machine learning and recent deep learning methods based on chemogenomic properties of drugs and target proteins have pushed this ...
Yuanyuan Zhang, Yingdong Wang, Chaoyong Wu, Lingmin Zhan, Aoyi Wang, Caiping Cheng, Jinzhong Zhao, Wuxia Zhang, Jianxin Chen, Peng Li   +9 more
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Triterpenoids from the Leaves of Diospyros digyna and Their PTP1B Inhibitory Activity

Molecules
Six new 2α-hydroxy ursane triterpenoids, 3α-cis-p-coumaroyloxy-2α,19α-dihydroxy-12-ursen-28-oic acid (1), 3α-trans-p-coumaroyloxy-2α,19α-dihydroxy-12-ursen-28-oic acid (2), 3α-trans-p-coumaroyloxy-2α-hydroxy-12-ursen-28-oic acid (3), 3β-trans-p ...
Lan Huang, Ziqi Wang, Fangxin Wang, Song Wang, Dezhi Wang, Meihua Gao, Hua Li, Min Song, Xiaoqi Zhang   +8 more
doaj   +1 more source

Directions in the modernization of modern seaports

Scientific Journal of Silesian University of Technology. Series Transport, 2018
Growing trade and the globalization of production and consumption have contributed to the increased importance of seaports. Maritime transport of bulk cargo is competitive. The carriage of general cargo is also growing, mainly through the widespread use of containers.
openaire   +2 more sources

TCMNet: an AI-driven strategy for optimizing traditional Chinese medicine

Chinese Medicine
Background Artificial intelligence (AI), particularly large language models (LLMs), have provided powerful tools for systematically modeling the complexity of traditional Chinese medicine (TCM).
Shuoyan Tan, Xin Shao, Xuting Zhang, Yizheng Dai, Boli Zhang, Yiyu Cheng, Xiaohui Fan   +6 more
doaj   +1 more source

A hedgehog cathelicidin-derived peptide exhibits antiviral activity against herpes simplex virus type 1 infection

Frontiers in Microbiology
Herpes simplex virus type 1 (HSV-1) is a widespread infectious virus that poses a substantial public health burden. With no specific curative therapy available and current antivirals providing only symptomatic relief, the development of new effective ...
Enjie Deng, Yaping Pei, Kun Yuan, Juan Yang, Suncheng-ai Cao, Xinyan Yang, Guilan Li, Libin Liang, Lin Jin, Tengyu Zhu   +9 more
doaj   +1 more source

A Natural Peptide from the American Cockroach Suppresses Feline Infectious Peritonitis Virus

Biology
Feline infectious peritonitis virus (FIPV) causes a fatal and immune-mediated disease in cats with limited treatment options. Natural products offer promising antiviral candidates, but animal-derived peptides remain underexplored.
Tengyu Zhu, Jinfeng Hou, Tong Jing, Yibo Wu, Rui Meng, Ruobing Liu, Kun Yuan, Sunchengai Cao, Xinyan Yang, Jiayi Wang, Ziyin Wang, Zhengyan Zhu, Yaogui Sun, Lin Jin   +13 more
doaj   +1 more source