Results 231 to 240 of about 2,063,794 (297)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Biochar for the adsorption of endocrine-disrupting chemicals: performance, mechanisms, and strategies. [PDF]

RSC Adv
Gao X, Jia R, Zhang Y, Kang J, Zhang L, Ye H, Ren H.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases. [PDF]

Epigenetics
Lv F, Jin Y, Yu S, Yang X, Xia S, Ye X, Zhao Q, Hu Y, Zheng A, Wu Y, Tong J.   +10 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The dual regulatory role of METTL14-mediated m⁶A modification in tumorigenesis and its underlying mechanisms. [PDF]

Front Oncol
Yang Y, Chao L, Ao X, Liang J.
europepmc   +1 more source

NAT10 and ac4C modification in cancer immunity and metabolism: emerging mechanisms and therapeutic potential. [PDF]

J Transl Med
Yang Y, Chen C, Feng Y, Lv Q.
europepmc   +1 more source

Cancer-associated fibroblasts promote osimertinib resistance in non-small cell lung cancer cells via METTL1-mediated NET1 m⁷G modification. [PDF]

Cell Death Dis
Qian Y, Gong Z, Jia Y, Zhang Q, Cao L, Li B, Zhang J, Wang M, Wu X, Xu K.   +9 more
europepmc   +1 more source