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Posttranslational modifications in diabetes: Mechanisms and functions

Reviews in Endocrine and Metabolic Disorders, 2022
As one of the most widespread chronic diseases, diabetes and its accompanying complications affect approximately one tenth of individuals worldwide and represent a growing cause of morbidity and mortality. Accumulating evidence has proven that the process of diabetes is complex and interactive, involving various cellular responses and signaling ...
Ang Hu   +3 more
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The mechanism of the modification of silumin

Metal Science and Heat Treatment, 1970
1. The modifying effect of calcium is due to its deactivating influence on impurity particles that serve as solidification centers for eutectic silicon in unmodified Silumin. 2. Along with its possible influence on deactivation of impurities, the modifying effect of sodium is due to its reduction of the solidification rate of the ...
M. B. Gokhshtein, L. S. Vasil'eva
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Lipoprotein modification

Current Opinion in Lipidology, 1994
Oxidatively damaged LDL may be of pivotal importance in atherogenesis. This review focuses on the cellular pathways involved in LDL oxidation in vitro, the biological properties of oxidized LDL, and the implications of these findings for the role of LDL oxidation in the development of atherosclerosis.
A, Chait, J W, Heinecke
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Mechanisms of DNA methylation and histone modifications

2023
The field of genetics has expanded a lot in the past few decades due to the accessibility of human genome sequences, but still, the regulation of transcription cannot be explicated exclusively by the sequence of DNA of an individual. The coordination and crosstalk between chromatin factors which are conserved is indispensable for all living creatures ...
Santoshi, Acharjee   +3 more
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Considerations and Mechanical Modifications on a Smart Walker

2016 International Conference on Autonomous Robot Systems and Competitions (ICARSC), 2016
It is known that human mobility has the tendency to decrease, gradually, with age as a consequence of neurological, muscular and/or osteoarticular deterioration. Thus, in an aging society, devices that provide mobility assistance and ambulatory daily exercises are essential for the health and life quality of such individuals.
Joana Alves   +6 more
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On the Mechanism of Urea‐Induced Titania Modification

Chemistry – A European Journal, 2009
AbstractThe mechanism of surface modification of titania by calcination with urea at 400 °C was investigated by substituting urea by its thermal decomposition products. It was found that during the urea‐induced process titania acts as a thermal catalyst for the conversion of intermediate isocyanic acid to cyanamide. Trimerization of the latter produces
Dariusz, Mitoraj, Horst, Kisch
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Mechanisms of tubulin modification by phosphatidylcholine hydroperoxides

Lipids, 2000
AbstractThe interaction of lipid peroxides with cellular proteins has been postulated to contribute to cellular aging. A potential target for such effects is tubulin, the building block of microtubules. We examined the concentration‐dependent effects of phosphatidylcholine hydroperoxides on the ability of tubulin to polymerize into microtubules.
M, Kawakami, L, Ward, H, Doi
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The Mechanics of Modification

1963
In earlier chapters we have considered many aspects of the technique of engine modification. In this final chapter we shall discuss a few of the practical problems one meets when applying these techniques. This chapter is something of a hotch-potch with very little logic in its arrangement, but a liberal use of headings will help the reader to find a ...
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Simple mechanisms for the modification of homotetrameric proteins

Journal of Theoretical Biology, 1971
Abstract The kinetics of the irreversible modification of homotetrameric proteins are elaborated theoretically, assuming: (1) all-in-one; (2) one-intermediate; and (3) one-by-one mechanisms. A method is proposed to determine the mechanism of modification and the fractional amount of different enzyme forms originally present in the protein ...
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