Results 131 to 140 of about 600,227 (293)

Request strategies and modification devices as performed by Czech EFL learners: A focus on borrowing objects

open access: yes, 2023
This study presents an analysis of informal written requests from the national school-leaving exam and simulated spoken requests collected via Written Discourse Completion Task (WDCT) to describe pragmalinguistic features used by Czech EFL learners in ...
Lahodová Vališová, Marie   +1 more
core  

Astringency Modification of Mandilaria Wines: Vineyard and Winery Strategies

open access: yesBeverages
This paper aims to explore the impact of targeted viticultural and enological interventions on reducing the astringency of wines made solely with Mandilaria, a red Vitis Vinifera L. grape variety.
Christina Karadimou   +6 more
doaj   +1 more source

Epigenetic Modifications in Osteosarcoma: Mechanisms and Therapeutic Strategies

open access: yesLife
Osteosarcoma (OS), the most common primary bone cancer of mesenchymal origin in children and young adolescents, remains a challenge due to metastasis and resistance to chemotherapy. It displays severe aneuploidy and a high mutation frequency which drive tumor initiation and progression; however, recent studies have highlighted the role of epigenetic ...
Maria A. Katsianou   +4 more
openaire   +2 more sources

Fluorination strategy toward chemical and functional modification

open access: yesFundamental Research
Fluorination is a powerful strategy for chemical and functional modification of materials because the introduction of fluorine atoms can alter the physical, chemical and electronic properties of a material and thereby result in improved key properties.
Haotian Qiu   +2 more
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Recent Modification Strategies of MoS2 towards Electrocatalytic Hydrogen Evolution

open access: yes
Hydrogen production by the electrolysis of water is a green and efficient method, which is of great significance for achieving sustainable development. Molybdenum disulfide (MoS2) is a promising electrocatalyst for hydrogen evolution reaction (HER) due ...
Lei Liu   +4 more
core   +1 more source

Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies

open access: yesExperimental Hematology & Oncology
Cancer remains the leading cause of mortality worldwide, and the emergence of drug resistance has made the identification of new therapeutic targets imperative.
Mengqi Lv   +3 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

THE EDUCATIONAL UTILITY OF COGNITIVE BEHAVIOR MODIFICATION STRATEGIES WITH CHILDREN: A QUANTITATIVE SYNTHESIS.

open access: yes, 1987
THE EDUCATIONAL UTILITY OF COGNITIVE BEHAVIOR MODIFICATION STRATEGIES WITH CHILDREN: A QUANTITATIVE ...
GARY A. DUZINSKI (7965620)
core  

Strategies for the Design and Discovery of Novel Antibiotics using Genetic Engineering and Genome Mining

open access: yes, 2014
Most bioactive natural products currently known are synthesized by members of the Actinomycetales order. The development of genetic engineering provides novel genetic tools for the modification of known antibiotics and other bioactive compounds to ...
Olano Álvarez, Carlos   +2 more
core   +1 more source

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