Results 1 to 10 of about 1,139,517 (313)

Protein modification and degradation in ferroptosis. [PDF]

Redox Biol
Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox system, encompassing pro-oxidative proteins and antioxidative proteins. These proteins undergo precise control through diverse post-translational modifications, including ubiquitination, phosphorylation, acetylation, O-GlcNAcylation, SUMOylation, methylation, N ...
Wang Y, Yan D, Liu J, Tang D, Chen X.
europepmc   +4 more sources

Protein modification in neurodegenerative diseases. [PDF]

MedComm (2020)
AbstractPosttranslational modifications play a crucial role in governing cellular functions and protein behavior. Researchers have implicated dysregulated posttranslational modifications in protein misfolding, which results in cytotoxicity, particularly in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease ...
Ramazi S, Dadzadi M, Darvazi M, Seddigh N, Allahverdi A.   +4 more
europepmc   +4 more sources

Highly Expressed Soluble Recombinant Anti-GFP VHHs in Escherichia coli via Optimized Signal Peptides, Strains, and Inducers

Frontiers in Molecular Biosciences, 2022
Antigen-binding variable domains of the H chain of heavy-chain antibodies (VHHs), also known as nanobodies (Nbs), are of great interest in imaging technique, disease prevention, diagnosis, and therapy.
Shuangying Chao, Shuangying Chao, Yuhang Liu, Yuhang Liu, Ning Ding, Ning Ding, Yue Lin, Yue Lin, Qian Wang, Qian Wang, Junwen Tan, Junwen Tan, Wei Li, Wei Li, Yang Zheng, Yang Zheng, Xuejun Hu, Xuejun Hu, Junming Li   +18 more
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Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1

npj Precision Oncology, 2021
E74-like ETS transcription factor 5 (ELF5) is involved in a wide spectrum of biological processes, e.g., mammogenesis and tumor progression. We have identified a list of p300-interacting proteins in human breast cancer cells.
Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu   +8 more
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DACH1 inhibits breast cancer cell invasion and metastasis by down-regulating the transcription of matrix metalloproteinase 9

Cell Death Discovery, 2021
Human Dachshund homolog 1 (DACH1) is usually defined as a tumor suppressor, which plays an influential role in tumor growth and metastasis in a variety of cancer cells. However, the underlying mechanisms in these process are not yet fully clarified.
Sattout Aman, Yanan Li, Yunmeng Cheng, Yuxi Yang, Linlin Lv, Bowen Li, Kangkai Xia, Shujing Li, Huijian Wu   +8 more
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TIMELESS inhibits breast cancer cell invasion and metastasis by down-regulating the expression of MMP9

Cancer Cell International, 2021
Breast cancer is the first killer leading to female death, and tumor metastasis is one of the important factors leading to the death of patients, but the specific mechanism of breast cancer metastasis is not very clear at present.
Bowen Li, Liying Mu, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Bashir Ahmad, Shujing Li, Huijian Wu   +8 more
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FBXL10 promotes EMT and metastasis of breast cancer cells via regulating the acetylation and transcriptional activity of SNAI1

Cell Death Discovery, 2021
F-box and leucine-rich repeat protein 10 (FBXL10) has been reported to play a regulatory role in the initiation and development of breast cancer. Bioinformatics analyses revealed that FBXL10 may involve in the process of cytoskeleton organization.
Yangyang Yang, Binggong Zhao, Linlin Lv, Yuxi Yang, Shujing Li, Huijian Wu   +5 more
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Cryptochrome 2 acetylation attenuates its antiproliferative effect in breast cancer

Cell Death and Disease, 2023
Breast cancer is the most commonly diagnosed cancer, and its global impact is increasing. Its onset and progression are influenced by multiple cues, one of which is the disruption of the internal circadian clock.
Kangkai Xia, Shujing Li, Yuxi Yang, Xiaoxia Shi, Binggong Zhao, Linlin Lv, Zhiqiang Xin, Jie Kang, Ping Ren, Huijian Wu   +9 more
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Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress

Cells, 2022
In response to environmental stimuli, cells make a series of adaptive changes to combat the injury, repair the damage, and increase the tolerance to the stress.
Yanan Li, Shujing Li, Huijian Wu
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KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner

Cell Death and Disease, 2023
Breast cancer is the most common cancer affecting women worldwide. Many genes are involved in the development of breast cancer, including the Kruppel Like Factor 12 (KLF12) gene, which has been implicated in the development and progression of several ...
Yanan Li, Shujing Li, Xiaoxia Shi, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Yvlin Li, Linlin Lv, Ping Ren, Huijian Wu   +9 more
doaj   +1 more source