Results 21 to 30 of about 1,139,517 (313)

Calibrating Catalytic DNA Nanostructures for Site-Selective Protein Modification. [PDF]

Chemistry, 2022
Many biomedical fields rely on proteins that are selectively modified with novel chemical entities. These are often attached using reactive or catalytic moieties, but the position where these moieties are attached is often poorly controlled. In this work,
Keijzer JF, Zuilhof H, Albada B.
europepmc   +2 more sources

Discovering the landscape of protein modifications [PDF]

Molecular Cell, 2021
Protein modifications modulate nearly every aspect of cell biology in organisms, ranging from Archaea to Eukaryotes. The earliest evidence of covalent protein modifications was found in the early 20th century by studying the amino acid composition of proteins by chemical hydrolysis. These discoveries challenged what defined a canonical amino acid.
E. Keith Keenan, Derek K. Zachman, Matthew D. Hirschey   +2 more
openaire   +2 more sources

Correction: TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway

Cell Death and Disease, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Qingzi Chen, Yubo Zhou, Lifen Zhou, Zhaodi Fu, Chuntao Yang, Lei Zhao, Shuni Li, Yan Chen, Yousen Wu, Zhenwei Ling, Yufeng Wang, Jianrong Huang, Jianhua Li   +12 more
doaj   +1 more source

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Journal of Hematology & Oncology, 2016
Background Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML).
Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Bing Z. Carter, Xuejun Wang, Xianping Shi, Jinbao Liu   +13 more
doaj   +1 more source

Mild‐Photothermal Effect Induced High Efficiency Ferroptosis‐Boosted‐Cuproptosis Based on Cu2O@Mn3Cu3O8 Nanozyme

Advanced Science, 2023
A core‐shell‐structured Cu2O@Mn3Cu3O8 (CMCO) nanozyme is constructed to serve as a tumor microenvironment (TME)‐activated copper ionophore to achieve safe and efficient cuproptosis.
Wei Chen, Wenyu Xie, Zhimin Gao, Chen Lin, Meiling Tan, Yaru Zhang, Zhiyao Hou   +6 more
doaj   +1 more source

Protein Modification by Adenine Propenal [PDF]

Chemical Research in Toxicology, 2014
Base propenals are products of the reaction of DNA with oxidants such as peroxynitrite and bleomycin. The most reactive base propenal, adenine propenal, is mutagenic in Escherichia coli and reacts with DNA to form covalent adducts; however, the reaction of adenine propenal with protein has not yet been investigated.
Shuck, Sarah C., Wauchope, Orrette R., Rose, Kristie L., Kingsley, Philip J., Rouzer, Carol A., Shell, Steven M., Sugitani, Norie, Chazin, Walter J., Zagol-Ikapitte, Irene, Boutaud, Olivier, Oates, John A., Galligan, James J., Beavers, William N., Marnett, Lawrence J.   +13 more
openaire   +2 more sources

Extensive Anti-CoA Immunostaining in Alzheimer’s Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A [PDF]

, 2021
Alzheimer’s disease (AD) is a neurodegenerative disorder, accounting for at least two-thirds of dementia cases. A combination of genetic, epigenetic and environmental triggers is widely accepted to be responsible for the onset and development of AD ...
Surjit Kaila Srai, Tammaryn Lashley, Stefan G. D. Rüdiger, Bradshaw, Aaron, Filonenko, V, Wallworth, S, Oksana Malanchuk, Skehel, Mark, Costello Heaven, Neve, Skehel, M, J. Mark Cooper, Koopman, Margreet B., Cellular Protein Chemistry, Lashley, Tammaryn, Samantha Wallworth, Filonenko, Valeriy, Sub Cellular Protein Chemistry, Gout, Ivan, Lashley, T, de Silva, R, de Silva, Rohan, Tossounian, M-A, Srai, SK, Wallworth, Samantha, Neve Costello Heaven, Malanchuk, O, Sew Peak-Chew, Cooper, JM, Gout, I, Mark Skehel, Aaron Bradshaw, Koopman, MB, Ivan Gout, Rüdiger, SGD, Valeriy Filonenko, Bradshaw, A, Margreet B. Koopman, Cooper, J. Mark, Rohan de Silva, Peak-Chew, Sew, Rüdiger, Stefan G.D., Peak-Chew, S, Srai, Surjit Kaila, Maria-Armineh Tossounian, Costello Heaven, N, Tossounian, Maria Armineh, Malanchuk, Oksana   +46 more
core   +1 more source

Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition

Journal of Experimental & Clinical Cancer Research, 2017
Background Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract.
Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng, Jinbao Liu   +14 more
doaj   +1 more source

CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3

Cell Death and Disease, 2021
Autophagy is an important biological process in normal cells. However, how it affects tumor progression still remains poorly understood. Herein, we demonstrated that the oncogenic protein Chromodomain-helicase-DNA-binding-protein 1-like gene (CHD1L ...
Xiaofeng Zhang, Yinshan Bai, Li Huang, Shanshan Liu, Yanxuan Mo, Wei Cheng, Guangliang Wang, Zhiming Cao, Xiaogang Chen, Huiqing Cui, Ling Qi, Lei Ma, Ming Liu, Xin-Yuan Guan, Ning-Fang Ma   +14 more
doaj   +1 more source

Kinetics of protein modification reactions [PDF]

Biochemical Journal, 1984
or partially covalent, bond of the protein under study (Cohen, 1970), hence also the more general term 'covalent modification' (Brocklehurst, 1982). Protein modification studies have so far aimed at: (a) the determination of the kind and number of reactive groups of the protein molecule under study, (b) the development of site-specific protein ...
openaire   +3 more sources