Results 11 to 20 of about 1,139,517 (313)

Site-Selective Protein Modification via Peptide-Directed Proximity Catalysis. [PDF]

ACS Omega
Proximity catalysis exploits ligand-binding for localised, catalytic protein modification. In this work, we introduce catalyst-functionalised peptides as versatile ligands for this approach.
Raynal L, Nabarro J, Miller LM, Dowle AA, Moul SL, Masithi P, Johnson SD, Fascione MA, Spicer CD.   +8 more
europepmc   +2 more sources

Trend of disease burden and risk factors of breast cancer in developing countries and territories, from 1990 to 2019: Results from the Global Burden of Disease Study 2019

Frontiers in Public Health, 2023
BackgroundThe incidence, mortality, burden of disability-adjusted life years (DALYs), and attributable risk factors of breast cancer vary significantly by country or region, particularly between developing and developed countries.
Linlin Lv, Linlin Lv, Binggong Zhao, Jie Kang, Shujing Li, Huijian Wu   +5 more
doaj   +1 more source

Alteration of rhesus macaque serum N-glycome during infection with the human parasitic filarial nematode Brugia malayi

Scientific Reports, 2022
Serum N-glycan profiling studies during the past decades have shown robust associations between N-glycan changes and various biological conditions, including infections, in humans.
Laudine M. C. Petralia, Esrath Santha, Anna-Janina Behrens, D. Linh Nguyen, Mehul B. Ganatra, Christopher H. Taron, Vishal Khatri, Ramaswamy Kalyanasundaram, Angela van Diepen, Cornelis H. Hokke, Jeremy M. Foster   +10 more
doaj   +1 more source

Protein Modification at Tyrosine with Iminoxyl Radicals

, 2021
Post-translational modifications (PTMs) of proteins are a biological mechanism for reversibly controlling protein function. Synthetic protein modifications (SPMs) at specific canonical amino acids can mimic PTMs.
Takashi, Ishiyama, Yohei, Seki, Katsuya, Maruyama, Motomu, Kanai, Kounosuke, Oisaki, Kentaro, Sakai, Takaya, Togo   +6 more
core   +1 more source

Deep Learning–Based Advances In Protein Posttranslational Modification Site and Protein Cleavage Prediction

, 2022
Posttranslational modification (PTM) is a ubiquitous phenomenon in both eukaryotes and prokaryotes which gives rise to enormous proteomic diversity. PTM mostly comes in two flavors: covalent modification to polypeptide chain and proteolytic cleavage ...
Pakhrin, Subash C., Saigo, Hiroto, KC, Dukka, Pokharel, Suresh, KC, Dukka B.   +4 more
core   +1 more source

Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression

Cancer Cell International, 2019
Background Metastasis is an important factor in the poor prognosis of breast cancer. As an important core clock protein, brain and muscle arnt-like 1 (BMAL1) is closely related to tumorigenesis.
Jian Wang, Shujing Li, Xiahui Li, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Miao Wang, Huijian Wu   +9 more
doaj   +1 more source

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Cell Reports, 2013
Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied.
Xiaofen Li, Shouting Liu, Hongbiao Huang, Ningning Liu, Chong Zhao, Siyan Liao, Changshan Yang, Yurong Liu, Canguo Zhao, Shujue Li, Xiaoyu Lu, Chunjiao Liu, Lixia Guan, Kai Zhao, Xiaoqing Shi, Wenbin Song, Ping Zhou, Xiaoxian Dong, Haiping Guo, Guanmei Wen, Change Zhang, Lili Jiang, Ningfang Ma, Bing Li, Shunqing Wang, Huo Tan, Xuejun Wang, Q. Ping Dou, Jinbao Liu   +28 more
doaj   +1 more source

Protein Modification by Arginylation

Chemistry & Biology, 2011
The modification of protein by arginine catalyzed by arginyltransferases (ATE1) described by the Kashina group in this issue shows that arginylation of protein occurs widely in biology and is being recognized as a key regulatory reaction such as phosphorylation of proteins (Wang et al., 2011).
Kaji, Hideko, Kaji, Akira
openaire   +2 more sources

Selectivity and stability of N-terminal targeting protein modification chemistries

, 2022
Protein N-termini provide uniquely reactive motifs for single site protein modification. Though a number of reactions have been developed to target this site, the selectivity, generality, and stability of the conjugates formed has not been studied.
Martin, Fascione, Nicholas, Yates, Lydia, Barber, Glyn, Hemsworth, Alison, Parkin, Christopher, Spicer, Paul, Genever   +6 more
core   +1 more source

Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2023
Background LINC00173 had been reported as a cisplatin (cis-diamminedichloroplatinum, DDP) chemotherapy-resistant inducer in small-cell lung cancer (SCLC) and lung squamous cell carcinoma (LUSC). This study aimed to display reverse data for LINC00173 as a
Xingyu Tao, Yang Li, Songqing Fan, Liyang Wu, Jianyang Xin, Yun Su, Xiaoyang Xian, Yingying Huang, Rongquan Huang, Weiyi Fang, Zhen Liu   +10 more
doaj   +1 more source