Results 21 to 30 of about 13,027,602 (171)

Combination of modified carbapenem inactivation method (mCIM) and EDTA-CIM (eCIM) for phenotypic detection of carbapenemase-producing Enterobacteriaceae. [PDF]

BMC Microbiol, 2020
Abstract Background Carbapenemase-resistant Enterobacteriaceae (CRE) cause many serious infections resulting in increasing treatment cost, prolonged hospitalization, and mortality rate. Reduced expression and/or mutations of porins and the presence of carbapenemase promote Enterobacteriaceae survival under carbapenem ...
Tsai YM, Wang S, Chiu HC, Kao CY, Wen LL.   +4 more
europepmc   +5 more sources

EDTA-Modified Carbapenem Inactivation Method: a Phenotypic Method for Detecting Metallo-β-Lactamase-Producing Enterobacteriaceae. [PDF]

J Clin Microbiol, 2019
The increase in the prevalence and impact of infections caused by carbapenemase-producing Enterobacteriaceae is a global health concern. Therefore, rapid and accurate methods to detect these organisms in any clinical microbiology laboratory, including those in resource-limited settings, are essential to prevent and ...
Sfeir MM, Hayden JA, Fauntleroy KA, Mazur C, Johnson JK, Simner PJ, Das S, Satlin MJ, Jenkins SG, Westblade LF.   +9 more
europepmc   +4 more sources

The prediction values of carbapenemase detection methods and carbapenem susceptibility testing for clinical outcomes of patients with Acinetobacter bacteremia under carbapenem treatment

Journal of Microbiology, Immunology and Infection, 2022
Background: Carbapenem-resistant Acinetobacter species have emerged as notorious pathogens causing nosocomial infections. Several phenotypic methods have been developed for detecting carbapenemase production in Enterobacteriaceae.
Yi-Tzu Lee, Tzu-Wen Huang, I-Fan Liu, Shu-Chen Kuo, Ya-Sung Yang, Pei-Ying Lin, Chang-Pan Liu, Yuag-Meng Liu, Te-Li Chen, Fu-Der Wang, Yung-Chih Wang   +10 more
doaj   +3 more sources

Detection of Carbapenemase Production by Modified Carbapenem Inactivation Method among Carbapenem Resistant Gram- negative Bacilli at a Tertiary Care Centre in Coimbatore, Tamil Nadu, India

NATIONAL JOURNAL OF LABORATORY MEDICINE, 2023
Introduction: In the era of increasing antimicrobial resistance, knowing the mechanism of carbapenem resistance can aid in choosing an apt drug for treatment of patients. There are only few studies estimating the burden of carbapenem resistance and determining the mechanism of resistance among the isolates in our locale.
Varshini Baskaran, Lavanya Jeyamani, Deepak Thangaraju, Ranjithkumar Sivaraj, Jayalakshmi Jayarajan   +4 more
openaire   +3 more sources

The optimized carbapenem inactivation method for objective and accurate detection of carbapenemase-producing Acinetobacter baumannii

Frontiers in Microbiology, 2023
The modified carbapenem inactivation method (mCIM) recommended by the Clinical and Laboratory Standards Institute is not applicable for detecting carbapenemases in Acinetobacter baumannii. Four currently reported phenotypic detection methods, namely, the
Sirui Zhang, Peng Mi, Peng Mi, Jingdan Wang, Pu Li, Kai Luo, Shuyan Liu, Mona Mohamed Al-Shamiri, Jin’e Lei, Simin Lai, Bei Han, Yanjiong Chen, Lei Han, Shaoshan Han   +13 more
doaj   +3 more sources

An agar plate-based modified carbapenem inactivation method (p-mCIM) for detection of carbapenemase-producing Enterobacteriaceae

Journal of Microbiological Methods, 2020
Detecting carbapenemase-producing Enterobacteriaceae (CPE) has become increasingly difficult due to the emergence of diverse enzymes. The aim of the study was to evaluate an agar plate-based modified carbapenem inactivation method (p-mCIM) for detection of CPE. Stock strains and clinical isolates of CPE were used to evaluate the p-mCIM.
Jung-Hyun, Byun, Yonghee, Seo, Daewon, Kim, Myungsook, Kim, Hyukmin, Lee, Dongeun, Yong, Kyungwon, Lee, Yunsop, Chong   +7 more
openaire   +4 more sources

Blood-Modified Carbapenem Inactivation Method: a Phenotypic Method for Detecting Carbapenemase-Producing Enterobacteriaceae Directly from Positive Blood Culture Broths. [PDF]

J Clin Microbiol, 2020
A variant of the modified carbapenem inactivation method (mCIM) was developed to detect carbapenemase activity directly from positive blood culture broths. The method, termed “Blood-mCIM,” was evaluated using Bactec blood culture bottles (Becton, Dickinson and Company, Franklin Lakes, NJ) inoculated with 27 different carbapenemase ...
Sfeir MM, Satlin MJ, Fauntleroy KA, Jenkins SG, Westblade LF.   +4 more
europepmc   +4 more sources

Performance of seven carbapenemase detection assays in Pseudomonas aeruginosa across different epidemiological settings: a multicenter cross-sectional study [PDF]

Journal of Clinical Microbiology
The detection of carbapenemases in Pseudomonas aeruginosa remains challenging due to a great variety of other resistance mechanisms, and most laboratories, therefore, do not test for them.
Lukas Schaffarczyk, Rebekka Laufenberg, Timo J. B. van Eldijk, Niels Pfennigwerth, Sören Gatermann, Axel Hamprecht   +5 more
doaj   +2 more sources

Application of Modified Carbapenem Inactivation Method and Its Derivative Tests for the Detection of Carbapenemase-Producing Aeromonas

Infection and Drug Resistance, 2021
Yunying Wang,1 Hui Liu,2 Lijun Zhang,1 Bin Sun1 1Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Blood Transfusion, The First Affiliated Hospital of ...
Wang Y, Liu H, Zhang L, Sun B
doaj   +2 more sources

Assessment of the Diagnostic Accuracy of the Modified Hodge Test and Modified Carbapenem Inactivation Method for Identifying Carbapenem Resistance Mechanisms in Klebsiella pneumoniae: A Whole Genome Sequencing-Based Exploratory Study. [PDF]

Cureus
 Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major public health concern, particularly in immunocompromised and critically ill patients. Colistin and tigecycline are among the last-resort treatment options, while the primary driver of CRKP emergence is carbapenemase production, especially Klebsiella pneumoniae carbapenemase (KPC) and metallo-
Chakraborty D, Bhatia M, Gupta P, Nagaraj G, Shamanna V, Srinitha P, Ashwini KV, Ravikumar KL.   +7 more
europepmc   +3 more sources