Results 61 to 70 of about 13,027,602 (171)

Image_1_The optimized carbapenem inactivation method for objective and accurate detection of carbapenemase-producing Acinetobacter baumannii.TIF

, 2023
The modified carbapenem inactivation method (mCIM) recommended by the Clinical and Laboratory Standards Institute is not applicable for detecting carbapenemases in Acinetobacter baumannii. Four currently reported phenotypic detection methods, namely, the
Jingdan Wang (16537701), Simin Lai (15241801), Shuyan Liu (321855), Mona Mohamed Al-Shamiri (16537704), Shaoshan Han (10161066), Peng Mi (1359006), Yanjiong Chen (15241810), Lei Han (150108), Bei Han (158035), Jin’e Lei (496105), Pu Li (119107), Kai Luo (769190), Sirui Zhang (1410760)   +12 more
core   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Evaluate the Modified Carbapenem Inactivation Method for Phenotypic Detection of Carbapenemase Production Among Gram-Negative Bacteria

Archives of Pediatric Infectious Diseases, 2022
Background: Global growing infections by multi-drug resistance (MDR) or extensively drug-resistant (XDR) bacteria are a serious public health problem which can increase the rate of mortality and morbidity even in children. Carbapenem is the last choice therapy in case of antibiotic-resistant bacteria presence.
Shahnaz Armin, Abdollah Karimi, Masoud Alebouyeh, Sedigheh Rafiei Tabatabaei, Maryam Rajabnejad, Roxana Mansour Ghanaiee, Seyed Alireza Fahimzad, Nafiseh Abdollahi, Leila Azimi   +8 more
openaire   +1 more source

Comparative study of phenotypic-based detection assays for carbapenemase-producing Acinetobacter baumannii with a proposed algorithm in resource-limited settings.

PLoS ONE, 2021
The increasing incidence of carbapenem resistance in Acinetobacter baumannii is a critical concern worldwide owing to the limitations of therapeutic alternatives. The most important carbapenem resistance mechanism for A.
Piyatip Khuntayaporn, Krit Thirapanmethee, Pohnvipa Kanathum, Kanokwan Chitsombat, Mullika Traidej Chomnawang   +4 more
doaj   +2 more sources

Successful control of the first carbapenem-resistant Klebsiella pneumoniae outbreak in a Chinese hospital 2017–2019

Antimicrobial Resistance and Infection Control, 2020
Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered as a serious global threat. CRKPs occurred only sporadically in the Second Hospital of Shanxi Medical University.
Jiaying Zhu, Qi Li, Xiaoxia Li, Jianbang Kang, Yan Song, Junli Song, Donghong Yin, Jinju Duan   +7 more
doaj   +1 more source

Phenotypic detection of carbapenem-resistant Enterobacterales and carbapenem-resistant Pseudomonas aeruginosa by mCIM and eCIM and their ceftazidime-avibactam with aztreonam synergy profile in a tertiary care hospital in Eastern India

Asian Journal of Medical Sciences
Background: Worldwide, the emergence of carbapenem-resistant enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global concern to public health as they are responsible for several serious infections that lead to elevated ...
Payel Chanda , Sharmila Gupta , Saswati Chattopadhyay , Soma Bose   +3 more
doaj   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

Does the presence of multiple β-lactamases in Gram-negative bacilli impact the results of antimicrobial susceptibility tests and extended-spectrum β-lactamase and carbapenemase confirmation methods?

Journal of Global Antimicrobial Resistance, 2020
Objectives: Many multidrug-resistant Gram-negative bacilli (MDR-GNB) harbour multiple β-lactamases. The aim of this study was to assess the impact of multiple β-lactamase carriage on the accuracy of susceptibility tests and extended-spectrum β-lactamase (
Fred C. Tenover, Caitlin M. dela Cruz, Scott Dewell, Victoria M. Le, Isabella A. Tickler   +4 more
doaj   +1 more source

A Longitudinal Nine-Year Study of the Molecular Epidemiology of Carbapenemase-Producing Enterobacterales Isolated From a Regional Hospital in Taiwan: Predominance of Carbapenemase KPC-2 and OXA-48

Frontiers in Microbiology, 2022
Enterobacterales clinical isolates are now being resistant to clinically achievable concentrations of most commonly used antibiotics that makes treatment of hospitalized patients very challenging.
Tran Thi Thuy Duong, Ya-Min Tsai, Li-Li Wen, Hui-Chuan Chiu, Pek Kee Chen, Tran Thi Dieu Thuy, Pei-Yun Kuo, Jazon Harl Hidrosollo, Shining Wang, Yen-Zhen Zhang, Wei-Hung Lin, Wei-Hung Lin, Ming-Cheng Wang, Ming-Cheng Wang, Cheng-Yen Kao   +14 more
doaj   +1 more source

Structural compatibility between β‐lactams and substrate binding pockets of IMP‐1 and NDM‐1 determines the substrate spectrum

Bulletin of the Korean Chemical Society, EarlyView.
Chemical structures of three β‐lactam classes and the substrate‐binding pockets (SBPs) of B1 metallo‐β‐lactamases (MBLs) were compared. Structural compatibility between β‐lactams and MBL SBPs correlates with enzymatic activity, providing insights into the substrate spectrum of MBLs and β‐lactam resistance.
Kiwoong Kwak, Jiwon Yun, Donghyun Lee, Byung‐Jin Lee, Juyeon Lim, Jung Hun Lee, Sang Hee Lee, Soon Young Shin, Lin‐Woo Kang   +8 more
wiley   +1 more source