Results 41 to 50 of about 8,885,090 (257)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Perbandingan uji efektifitas antidepresan impramin HCL antara metode forced swimming test dan alat waterwhell pada mencit betina [PDF]

, 2003
Penelitian ini dilakukan untuk membandingkan efektivitas antidepresan Imipramin HCI antara metode Forced Swimming Test dan Alat Waterwheel dengan dosis 15 mg/kg BB sebanyak 0,3 ml/20 gBB.
Sanjaya, Siska
core   +1 more source

Evaluation of Antidepressant Effect of Ethanolic and Aqueous Extracts of Silybum marianum L. Seed in Mice

Journal of Medicinal Plants, 2007
Background: Depression is one of the most psychiatric disorders that there are many treatments for it. Milk thistle is a plant which has many pharmacologic effects such as antioxidant, anti-inflammatory and anticancer. It is reported that silymarin (main
Gh Karimi, M Saradeghi Keisari
doaj  

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Antidepressant-like effects of gallic acid: dual effect on serotonergic and catecholaminergic neurotransmissions

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Gallic acid (GA), 3,4,5-trihydroxybenzoic acid, is a phenolic acid derivative and a natural polyphenol found in tea leaves, grapes, berries and plants like Thuja, Quercus, Rhus, Camelia.
Nazli Turan, Ozgur Devrim Can, Yusuf Ozturk   +2 more
doaj  

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Development of Patient‐Reported Outcome Measures for Early Systemic Sclerosis Across Disease Subtypes

Arthritis Care &Research, Accepted Article.
Objective Existing patient‐reported outcome (PRO) measures for systemic sclerosis (SSc) have important limitations, including inadequate coverage of early disease and limited inclusion of diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) subtypes.
George J. Greene, Chelsea Rose Perschon, Emilie Jaeger, Alain Lescoat, David Cella, Dinesh Khanna   +5 more
wiley   +1 more source

Perbandingan efektivitas antidepresan imipramin HCI antara metode forced swimming test dan metode waterwhell pada mencit jantan [PDF]

, 2003
Depresi merupakan bentuk gangguan suasana hati yang ditandai dengan adanya karakteristik suasana hati yang berlebihan dengan gangguan fisiologis, kognitif dan psikomotor. Obat yang digunakan sebagai anti depresi adalah Irniprarnin HCI.
., Diana
core   +1 more source

Zinc and selenium supplementation mitigates depression like behaviors in rats

Journal of Applied Pharmaceutical Research
Background: Zinc (Zn) and selenium (Se) act as trace elements essential for neuronal health, and deficiencies in either are linked to mood disorders. Both Zn and Sodium selenate (Na₂SeO₄) have shown emerging potential as antidepressant or mood-modulating
Abhishek Bhatt, Himani Dumka, Deepika, Jyoti Joshi, Lata Bisht, Veerma Ram   +5 more
doaj   +1 more source