Results 101 to 110 of about 12,579 (242)
Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines [PDF]
, 2003 Obligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmania sp are responsible for the infection of hundreds of millions of individuals every year.
Boscardin, Silvia Beatriz +5 more
core +2 more sources
Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma
Cancer Medicine, Volume 14, Issue 21, November 2025.ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC incidence continues to rise due to metabolic dysfunction‐associated steatotic liver disease (MASLD), obesity ...
Muhammad Masroor Hussain +5 more
wiley +1 more source
Generation and evaluation of a recombinant modified vaccinia virus Ankara vaccine for rabies [PDF]
Vaccine, 2007 Modified vaccinia virus Ankara (MVA) has become a vaccine vector of choice for recombinant vaccine development. A MVA-based rabies vaccine would be advantageous for use as a vaccine for dogs (and wildlife), particularly if it proves innocuous and efficacious by the oral route.
Weyer, Jacqueline +4 more
openaire +3 more sources
PLoS ONE, 2015 BackgroundReplicating smallpox vaccines can cause severe complications in individuals with atopic dermatitis (AD). Prior studies evaluating Modified Vaccinia Ankara virus (MVA), a non-replicating vaccine in humans, showed a favorable safety and ...
Richard N Greenberg +14 more
doaj +1 more source
Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB/c mice
, 2014 Vaccinia virus (VACV) strain MVA is a highly attenuated vector for vaccines that is being explored in clinical trials. We compared the CD8(+) T-cell immunogenicity of MVA with that of a virulent laboratory strain of VACV (strain WR) in BALB/c mice by ...
Russell, Tiffany A. +1 more
core +1 more source
Modified Vaccinia Virus Ankara Preferentially Targets Antigen Presenting Cells in Vitro, Ex Vivo and in Vivo [PDF]
, 2017 Modified Vaccinia virus Ankara (MVA) is a promising vaccine vector with an excellent safety profile. However, despite extensive pre-clinical and clinical testing, surprisingly little is known about the cellular tropism of MVA, especially in relevant ...
Altenburg, A.F. (Arwen) +11 more
core +1 more source
Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head [PDF]
, 2016 Influenza viruses have a huge impact on public health. Current influenza vaccines need to be updated annually and protect poorly against antigenic drift variants or novel emerging subtypes.
Rimmelzwaan, G.F. (Guus) +2 more
core +1 more source
MedComm, Volume 6, Issue 9, September 2025.Plasmacytoid and CD141+ myeloid dendritic cells cooperate with CD8+ T cells in lymph nodes, which is associated with HIV levels in blood and tissue. The interaction with primed dendritic cells with Toll‐like receptor agonists increase HIV‐specific CD8+ T cell response and PD‐1 blocking further enhance this response.
Joana Vitallé +17 more
wiley +1 more source
Recombinant viruses as tools to induce protective cellular immunity against infectious diseases [PDF]
, 2010 Infections by intracellular pathogens such as viruses, some bacteria and many parasites, are cleared in most cases after activation of specific T cellular immune responses that recognize foreign antigens and eliminate infected cells.
Alexandre Vieira Machado +3 more
core +2 more sources