Results 111 to 120 of about 12,579 (242)

A synthetic biology approach for a vaccine platform against known and newly emerging serotypes of bluetongue virus [PDF]

, 2014
Bluetongue is one of the major infectious diseases of ruminants and is caused by Bluetongue virus (BTV), an arbovirus existing in nature in at least 26 distinct serotypes. Here, we describe the development of a vaccine platform for BTV.
Brunet, Silvie, Hamers, Claude, Hudelet, Pascal, Nunes, Sandro Filipe, Palmarini, Massimo, Ratinier, Maxime, Shaw, Andrew   +6 more
core   +2 more sources

The Role of Public Health Interventions and Control Measures During Mpox Outbreaks: Enhancing Strategies for Disease Prevention and Management

Public Health Challenges, Volume 4, Issue 3, September 2025.
This paper highlights key public health interventions and control strategies implemented during mpox outbreaks, emphasizing early detection, targeted prevention, and the role of vaccination and education in mitigating disease transmission. ABSTRACT Mpox (formerly—monkeypox) is the second viral pit break after COVID‐19.
Muhammad Shaheer Bin Faheem, Ahmed Ali Khan, Qasra Faheem, Hafiza Qurat Ul Ain, Wajiha Imam, Yusra Aimen, Raheel Ahmed   +6 more
wiley   +1 more source

Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection.

PLoS Pathogens
The outbreak of mpox since 2022 has driven the development of mpox virus (MPXV)-specific, subunit-based, next-generation vaccines, instead of the currently used live-attenuated vaccinia virus (VACV) vaccines.
Lijun Zhang, Chuanyu Liu, Chenxi Yang, Xueqi Xiao, Senyu Xu, Shengfeng Wan, Kun Xu, Yan Li, Lianpan Dai   +8 more
doaj   +1 more source

Role of Fibroblast‐Immune Crosstalk in Kidney, Lung, and Skin Tertiary Lymphoid Structures

Immunological Reviews, Volume 334, Issue 1, September 2025.
ABSTRACT Tertiary lymphoid structures (TLSs) are organized aggregates of lymphocytes, myeloid cells, and stromal cells that form at sites of inflammation, providing adaptive immune responses outside of secondary lymphoid organs (SLOs). Found in various pathological conditions—including chronic infections, cancer, organ transplantation, autoimmune ...
Amy Cross, Jennifer Shelley, Rebecca Newman, Jessica Strid, Alice E. Denton   +4 more
wiley   +1 more source

Ty Virus-Like Particles, DNA Vaccines and Modified Vaccinia Virus Ankara; Comparisons and Combinations

Biological Chemistry, 1999
Three types of vaccine, all expressing the same antigen from Plasmodium berghei, or a CD8+ T cell epitope from that antigen, were compared for their ability to induce CD8+ T cell responses in mice. Higher levels of lysis and numbers of IFN-gamma secreting T cells were primed with Ty virus-like particles and Modified Vaccinia Virus Ankara (MVA) than ...
Gilbert, S, Schneider, J, Plebanski, M, Hannan, C, Blanchard, T, Smith, G, Hill, A   +6 more
openaire   +2 more sources

Comparative pathogenicity of vaccinia virus and mpox virus infections in CAST/EiJ mice: Exploring splenomegaly and transcriptomic profiles

Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1376-1386, August 2025.
We successfully constructed CAST/EiJ mice models infected with low‐dose vaccinia virus (VACV‐L), high‐dose VACV (VACV‐H), and mpox virus (MPXV), demonstrating that VACV‐L and MPXV infections induced splenomegaly in mice, and VACV‐H infection caused mortality in mice.
Yongzhi Hou, Jianrong Ma, Baoying Huang, Na Li, Lin Zhu, Ziqing Jia, Jiasen Yang, Jingjing Zhang, Wenjie Tan, Jing Xue   +9 more
wiley   +1 more source

Vaccinia Virus LC16m8∆ as a Vaccine Vector for Clinical Applications

Vaccines, 2014
The LC16m8 strain of vaccinia virus, the active ingredient in the Japanese smallpox vaccine, was derived from the Lister/Elstree strain. LC16m8 is replication-competent and has been administered to over 100,000 infants and 3,000 adults with no serious ...
Minoru Kidokoro, Hisatoshi Shida
doaj   +1 more source

Vaccination in dermatology 2025: Update considering current recommendations of the German Standing Committee on Vaccination

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 8, Page 925-930, August 2025.
Summary The immunosuppressive and immunomodulatory treatment of dermatological patients necessitates the regular review and updating of standard vaccinations and vaccines indicated for specific conditions. The German Standing Committee on Vaccination (STIKO) at the Robert Koch Institute regularly publishes evidence‐based vaccination recommendations ...
Johanna Stoevesandt, Marc Schmalzing, Sophia Mohme, Matthias Goebeler   +3 more
wiley   +1 more source

Tertiary Lymphoid Structures in Tuberculosis: Persistence, Protection, and Pathology

Immunological Reviews, Volume 333, Issue 1, August 2025.
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major public health burden responsible for over a million deaths each year. A deeper understanding of the mechanisms that balance protective immunity and immunopathology is essential for developing more effective therapeutics.
Tiphaine M. N. Camarasa, Lorenzo Iseppi, David Schreiner, Carolyn G. King   +3 more
wiley   +1 more source

Replication-incompetent viral vaccine vectors ChAdOx1 and MVA as tools for evaluating T-cell responses to naturally processed antigens in vitro

Virus Research
Assessing T-cell responses is critical for vaccine development. In vitro methods using SARS-CoV-2 or recombinant vaccinia virus with B cells effectively activate T-cells but require stringent biosafety conditions.
Salik Nazki, Jesús Reiné, Reshma Kailath, Sarah Gilbert, Bruno Douradinha   +4 more
doaj   +1 more source