Results 131 to 140 of about 12,579 (242)

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming [PDF]

, 2018
Splenic CD169+ macrophages are located in the marginal zone to efficiently capture blood-borne pathogens. Here, we investigate the requirements for the induction of CD8+ T cell responses by antigens (Ags) bound by CD169+ macrophages. Upon Ag targeting to
Ahrens, Aichele, Asano, Backer, Barral, Berney, Bernhard, Carrasco, Ciavarra, Crocker, Crocker, Crocker, Delputte, den Haan, den Haan, Di Pilato, Dudziak, Eickhoff, Eloranta, Erikson, García-Vallejo, Gaya, Gerner, Gupta, Habbeddine, Hildner, Honke, Hor, Iannacone, Iborra, Iborra, Iyoda, Jung, Junt, Kastenmüller, Kawasaki, Klaas, Macauley, Martinez-Pomares, Phan, Phan, Puryear, Sagoo, Sancho, Schulz, Segura, Segura, Seiler, Sewald, Silvin, van den Berg, van Montfoort, Veninga, Vinson, Winkelmann, Zelenay, Zhang   +56 more
core   +5 more sources

Protective MVA-ST Vaccination Robustly Activates T Cells and Antibodies in an Aged-Hamster Model for COVID-19

Vaccines
Aging is associated with a decline in immune system functionality. So-called immunosenescence may impair the successful vaccination of elderly people. Thus, improved vaccination strategies also suitable for an aged immune system are required.
Sabrina Clever, Lisa-Marie Schünemann, Federico Armando, Christian Meyer zu Natrup, Tamara Tuchel, Alina Tscherne, Malgorzata Ciurkiewicz, Wolfgang Baumgärtner, Gerd Sutter, Asisa Volz   +9 more
doaj   +1 more source

Vaccines against mpox: MVA-BN and LC16m8

Expert Review of Vaccines
Introduction Global outbreaks involving mpox clade IIb began in mid-2022. Today, clade IIb and clade I outbreaks continue. Reliable mpox vaccines can prevent serious mpox disease and death.Areas covered Globally, two vaccines hold mpox indications ...
John D. Grabenstein, Adam Hacker
doaj   +1 more source

Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor. [PDF]

, 2015
Factors influencing T-cell responses are important for vaccine development but are incompletely understood. Here, vaccinia virus (VACV) protein N1 is shown to impair the development of both effector and memory CD8(+) T cells and this correlates with its ...
Ferguson, Brian J, Harman, Laura ER, Maluquer de Motes, Carlos, Ren, Hongwei, Smith, Geoffrey L, Sumner, Rebecca P   +5 more
core   +1 more source

Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques. [PDF]

, 2020
Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells.
Amara, Rama R, Beck, Zoltan, Dinasarapu, Ashok R, Elizaldi, Sonny R, Foehl, David H, Forthal, Donald N, Gach, Johannes S, Iyer, Smita S, Kozlowski, Pamela A, LaBranche, Celia C, Lakshmanappa, Yashavanth Shaan, Matyas, Gary R, Nguyen, Nancy K, Rane, Niharika N, Rao, Mangala, Reimann, Keith A, Schmidt, Brian A, Shen, Xiaoying, Tomaras, Georgia D, Trinh, Hung V, Verma, Anil, Walter, Korey A   +21 more
core  

Marker Rescue of the Host Range Restriction Defects of Modified Vaccinia Virus Ankara

Virology, 1998
The severely attenuated and host range (HR) restricted modified vaccinia virus Ankara (MVA) was derived by >500 passages in chick embryo fibroblasts, during which multiple deletions and mutations occurred. To determine the basis of the HR defect, we prepared cosmids from the parental vaccinia virus Ankara genome and transfected them into nonpermissive ...
Wyatt, Linda S., Carroll, Miles W., Czerny, Claus-Peter, Merchlinsky, Michael, Sisler, Jerry R., Moss, Bernard   +5 more
openaire   +2 more sources

A Recombinant Modified Vaccinia Ankara Vaccine Encoding Epstein–Barr Virus (EBV) Target Antigens: A Phase I Trial in UK Patients with EBV-Positive Cancer [PDF]

, 2014
Graham S. Taylor, Hui Jia, Kevin J. Harrington, Lip Wai Lee, James Turner, Kristin Ladell, David A. Price, Manjit Tanday, Jen Matthews, Claudia Roberts, Ceri Edwards, Lesley McGuigan, A. Hartley, Steve Wilson, Edwin P. Hui, Anthony T.�C. Chan, Alan B. Rickinson, Neil Steven   +17 more
openalex   +1 more source

Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis. [PDF]

J Immunother Cancer, 2023
Bella Á, Arrizabalaga L, Di Trani CA, Gonzalez-Gomariz J, Gomar C, Russo-Cabrera JS, Olivera I, Cirella A, Fernandez-Sendin M, Alvarez M, Teijeira A, Atay C, Medina-Echeverz J, Hinterberger M, Hochrein H, Melero I, Berraondo P, Aranda F.   +17 more
europepmc   +1 more source

Vaccinia virus protein B14, an inhibitor of NF-κB activation, and its counterpart in MVA

, 2010
Vaccinia virus (VACV) encodes multiple proteins which modulate NF-[kappa]B activation to evade the host immune response. One example is B14, a virulence factor that reduces NF-[kappa]B activation via interaction with IKK [Beta].
McCoy, Laura Ellen, McCoy, Laura Ellen
core   +1 more source

OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. [PDF]

J Exp Med, 2023
Yang N, Wang Y, Liu S, Tariq SB, Luna JM, Mazo G, Tan A, Zhang T, Wang J, Yan W, Choi J, Rossi A, Xiang JZ, Rice CM, Merghoub T, Wolchok JD, Deng L.   +16 more
europepmc   +1 more source