Results 51 to 60 of about 1,120,056 (288)
Local bulk physics from intersecting modular Hamiltonians
, 2017 We show that bulk quantities localized on a minimal surface homologous to a boundary region correspond in the CFT to operators that commute with the modular Hamiltonian associated with the boundary region.
Kabat, Daniel, Lifschytz, Gilad
core +1 more source
, 2011 We introduce Modular Markovian Logic (MML) for compositional continuous-time and continuous-space Markov processes. MML combines operators specific to stochastic logics with operators reflecting the modular structure of the models, similar to those used by spatial and separation logics.
Cardelli L., Larsen K.G., Mardare R.
openaire +3 more sources
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Holomorphic subgraph reduction of higher-point modular graph forms
, 2019 Modular graph forms are a class of modular covariant functions which appear in the genus-one contribution to the low-energy expansion of closed string scattering amplitudes.
Gerken, Jan E., Kaidi, Justin
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
DrugDiff: small molecule diffusion model with flexible guidance towards molecular properties
Journal of CheminformaticsWith the cost/yield-ratio of drug development becoming increasingly unfavourable, recent work has explored machine learning to accelerate early stages of the development process. Given the current success of deep generative models across domains, we here
Marie Oestreich +5 more
doaj +1 more source
State-of the-art and future perspective in co-culture systems for tendon engineering
Biomaterials and BiosystemsTendon is a connective tissue that links bone to muscle, allowing for maintenance of skeleton posture, joint movement, energy storage and transmission of muscle force to bone.
Salomé Guillaumin +2 more
doaj +1 more source
Frontiers in Physiology, 2021 Background: Exploring the potential biological relationships between heart failure with preserved ejection fraction (HFpEF) and concomitant diseases has been the focus of many studies for the establishment of personalized therapies. Hypertension (HTN) is
Guofeng Zhou +7 more
doaj +1 more source
Revisiting the modularity of modular polyketide synthases [PDF]
Current Opinion in Chemical Biology, 2009 Modularity is a highly sought after feature in engineering design. A modular catalyst is a multi-component system whose parts can be predictably interchanged for functional flexibility and variety. Nearly two decades after the discovery of the first modular polyketide synthase (PKS), we critically assess PKS modularity in the face of a growing body of ...
Chaitan, Khosla +2 more
openaire +2 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source