Results 81 to 90 of about 1,125,805 (286)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Design of Reconfigurable Planar Micro-Positioning Stages Based on Function Modules

IEEE Access, 2019
Micro-positioning stages, which are capable to meet the emerging industrial trend for performing various kinds of micro-manipulation and micro-assembly tasks are the crucial tools to miniaturize the products under ultra-high precision.
Bingxiao Ding, Zhi-Xin Yang, Xiao Xiao, Geng Zhang   +3 more
doaj   +1 more source

Infinite Product Exponents for Modular Forms

, 2016
Recently, D. Choi obtained a description of the coefficients of the infinite product expansions of meromorphic modular forms over $\Gamma_0(N)$. Using this result, we provide some bounds on these infinite product coefficients for holomorphic modular ...
Ali, Asra, Mani, Nitya
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Wide DC Output Voltage Range Buck-Boost 6-Module Y-Rectifier Featuring Full Power Delivery in 3-Phase and 1-Phase Operation

IEEE Access
Power factor correction rectifiers/inverters with wide input-output voltage ranges are instrumental in applications with widely varying dc voltages such as photovoltaic inverters.
David Menzi, Lorenz Kappeler, Patrick Ziegler, Davide Biadene, Johann W. Kolar   +4 more
doaj   +1 more source

Design method of modular bi-directional load-bearing and energy dissipating joints in the context of intelligent construction [PDF]

Archives of Civil Engineering
The requirements for structural performance and seismic performance in the field of civil engineering are increasing. Traditional building structures have certain limitations in extreme conditions such as earthquakes.
Hao Huang
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Modular and lower-modular elements of lattices of semigroup varieties [PDF]

, 2010
The paper contains three main results. First, we show that if a commutative semigroup variety is a modular element of the lattice Com of all commutative semigroup varieties then it is either the variety COM of all commutative semigroups or a nil-variety ...
L. N. Shevrin, V. Yu. Shaprynskǐi
core