Results 121 to 130 of about 3,246,445 (295)

A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone. [PDF]

FASEB J, 2020
Chen CD, Rudy MA, Zeldich E, Abraham CR.
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Manufactured Housing Board and Modular Building Advisory Board Joint Videoconference Meeting

, 2015
Idaho Div. of Building Safety Manufactured Housing Board and Modular Building Advisory Board joint minutes for Aug ...
Building Safety, Idaho Div. of;
core  

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Research on Design of Modular Apartment Building Product Platform for Manufacture and Assembly: A Case Study of the Modular Dormitory Building Design Project

Buildings
Currently, the global construction industry is facing challenges of stagnant efficiency and cost overruns. The potential of modular construction has not been fully unleashed due to the disconnection between design and manufacturing. This paper proposes a
Meng Wang, Xinrui Li, Feng Li, Jianghua Wang   +3 more
doaj   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Diretrizes da coordenação modular para o uso do bloco 44 cm como elemento principal em projetos arquitetônicos de alvenaria estrutural cerâmica [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-graduação em Engenharia Civil, Florianópolis, 2010A Alvenaria Estrutural é um sistema construtivo cuja racionalização se deve à coordenação dimensional e
Navarini, Cleila Cristina
core  

Enhancing modular construction supply chain: Drivers, opportunities, constraints, concerns, strategies, and measures

Developments in the Built Environment
Modular construction (MC) plays a pivotal role in fostering sustainable development. However, the promotion of MC in many jurisdictions has been encumbered by its prevailing undeveloped supply chain. This study aims to systematically explore the drivers,
Yidan Zhang, Mi Pan, Wei Pan, Yi Yang, Jiewen Wu   +4 more
doaj   +1 more source

Building a Modular Authorization Infrastructure [PDF]

, 2006
Authorization infrastructures manage privileges and render access control decisions, allowing \ud applications to adjust their behavior according to the privileges allocated to users. This paper describes \ud the PERMIS role based authorization infrastructure along with its conceptual authorisation, access \ud control, and trust models.
Chadwick, David W., Zhao, Gansen, Otenko, Sassa, Laborde, Romain, Su, Linying, Nguyen, Tuan Anh   +5 more
openaire