Results 101 to 110 of about 3,246,445 (295)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Mass Timber Modular Construction: Developments in Oregon [PDF]

, 2019
With the mass timber industry taking off in 2015 in Oregon, when DR Johnson Lumber in Riddle, OR started producing CLT panels, government officials were eager to support it for its promise of economic development in rural communities and also had hopes ...
Gershfeld, Mikhail, Sheine, Judith, Donofrio, Mark   +2 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The effectiveness of the modular technology lab in the Mosinee Middle School [PDF]

, 2002
Plan BTechnology Education has taken on many faces over the last twenty years. Making a transition from the Manual Arts to Industrial Arts took nearly fifty years.
Masterson, David W.
core  

Adopting Product Modularity in House Building to Support Mass Customisation [PDF]

, 2015
Product modularity is a concept that can contribute to the improvement of product quality and production efficiency in house-building. However, there is a lack of consensus in the literature on the concepts that define product modularity.
Rocha, Cecilia Gravina da, Formoso, Carlos, Formoso, Carlos Torres, Da Rocha, Cecília G., Rocha, Cecilia G. Da, Carlos Formoso, Patrícia Tzortzopoulos, Tzortzopoulos, Patricia, Cecília Rocha   +8 more
core   +1 more source

Modular Construction in the Digital Age: A Systematic Review on Smart and Sustainable Innovations

Buildings
Modular construction provides numerous benefits over traditional methods, especially when combined with digital technologies, offering a faster, safer, leaner, and more sustainable construction environment.
Diogo F. R. Parracho, Mohamed Nour El-Din, Iraj Esmaeili, Sara S. Freitas, Leonardo Rodrigues, João Poças Martins, Helena Corvacho, João M. P. Q. Delgado, Ana Sofia Guimarães   +8 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source