Scaffolds Mimicking the Tumor Microenvironment for In Vitro Malignancy Models
BiomimeticsThe tumor microenvironment (TME) plays a crucial role in regulating cancer cell proliferation, invasion, and drug resistance. Traditional two-dimensional (2D) in vitro models and animal models often fail to replicate the biochemical and biophysical ...
Maria Grazia Cascone +1 more
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Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho +9 more
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Modelling the tumor microenvironment in vitro in prostate cancer: current and future perspectives
ViewProstate cancer is the most common cancer in over 50% of countries and the third most common malignancy worldwide. The tumor microenvironment includes the non‐cancerous cells and components present in the tumor, including the molecules they produce and ...
Jiahua Pan, Kedi Yuan
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The Biofabrication of Diseased Artery In Vitro Models
Micromachines, 2022 As the leading causes of global death, cardiovascular diseases are generally initiated by artery-related disorders such as atherosclerosis, thrombosis, and aneurysm.
Chen Pan +4 more
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Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models
Cells, 2021 Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects cancer progression, metastasis and metabolism. Oxygen induces both proteomic and genomic changes within tumor cells, which cause many alternations in the tumor ...
Iwona Ziółkowska-Suchanek
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Tumor heterogeneity: preclinical models, emerging technologies, and future applications
Frontiers in Oncology, 2023 Heterogeneity describes the differences among cancer cells within and between tumors. It refers to cancer cells describing variations in morphology, transcriptional profiles, metabolism, and metastatic potential. More recently, the field has included the
Marco Proietto +14 more
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Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration
Stem Cells International, 2021 The microenvironment, or niche, regulates stem cell fate and improves differentiation efficiency. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are ideal cell source for bone tissue engineering.
Lingling E +11 more
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Transplantation of mouse iPSCs into testis of azoospermic mouse model: in vivo and in vitro study
Artificial Cells, Nanomedicine, and Biotechnology, 2019 This study aimed to induce spermatogenesis in azoospermic testis through induced pluripotent stem cells (iPSCs) derived spermatogonial stem cell-like cells (SSCLCs) after iPSCs in vivo and in vitro transplantation and three-dimensional organ culture. DiI-
Forouzan Rahmani +3 more
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Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine
Micromachines, 2021 The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in
Jisoo Kim, Jinah Jang, Dong-Woo Cho
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Application of microfluidic chips in the simulation of the urinary system microenvironment
Materials Today Bio, 2023 The urinary system, comprising the kidneys, ureters, bladder, and urethra, has a unique mechanical and fluid microenvironment, which is essential to the urinary system growth and development.
Changhao Hou +9 more
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