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Effect of Mechanical Microenvironment on Collagen Self-Assembly In Vitro
Journal of Functional Biomaterials, 2023 Collagen, as a structural protein, is widely distributed in the human body. Many factors influence collagen self-assembly in vitro, including physical-chemical conditions and mechanical microenvironment, and play a key role in driving the structure and ...
Leihan Han +5 more
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In Vitro 3D Cultures to Model the Tumor Microenvironment
Cancers, 2021 It is now well established that the tumor microenvironment plays a key role in determining cancer growth, metastasis and drug resistance. Thus, it is fundamental to understand how cancer cells interact and communicate with their stroma and how this crosstalk regulates disease initiation and progression.
Fabrizio FONTANA +2 more
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Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho +9 more
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Hydrogels to model 3D in vitro microenvironment of tumor vascularization. [PDF]
Adv Drug Deliv Rev, 2014 A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is
Song HH, Park KM, Gerecht S.
europepmc +4 more sources
Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment. [PDF]
PLoS ONE, 2018 Vasculature is an interface between the circulation and the hematopoietic tissue providing the means for hundreds of billions of blood cells to enter the circulation every day in a regulated fashion.
Surya Kotha +10 more
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Modelling the tumor microenvironment in vitro in prostate cancer: current and future perspectives
ViewProstate cancer is the most common cancer in over 50% of countries and the third most common malignancy worldwide. The tumor microenvironment includes the non‐cancerous cells and components present in the tumor, including the molecules they produce and ...
Kedi Yuan +4 more
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Integrating mechanical cues in in vitro models of immune-related fibrotic diseases [PDF]
Frontiers in ImmunologyFibrosis is a pathological process characterized by excessive deposition of extracellular matrix (ECM) and tissue stiffening, leading to organ failure and representing a common end-stage manifestation of numerous chronic diseases. The immune system plays
Chaoyang Song +17 more
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New Frontiers in modeling the lipedema microenvironment in vitro
Frontiers in Cell and Developmental BiologyLipedema is a chronic and often debilitating adipose tissue disorder that primarily affects women. The disease is characterized by disproportionate and symmetrical accumulation of subcutaneous fat in the extremities.
Khushi Soni, Rosalyn D. Abbott
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Scaffolds Mimicking the Tumor Microenvironment for In Vitro Malignancy Models
BiomimeticsThe tumor microenvironment (TME) plays a crucial role in regulating cancer cell proliferation, invasion, and drug resistance. Traditional two-dimensional (2D) in vitro models and animal models often fail to replicate the biochemical and biophysical ...
Elisabetta Rosellini +1 more
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The Biofabrication of Diseased Artery In Vitro Models
Micromachines, 2022 As the leading causes of global death, cardiovascular diseases are generally initiated by artery-related disorders such as atherosclerosis, thrombosis, and aneurysm.
Chen Pan +4 more
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