Results 21 to 30 of about 348,397 (157)
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To establish an in vitro culture model mimicking tumor microenvironment using hydrogel microspheres and fresh primary pancreatic cancer cells.Methods·The morphological distribution of the hydrogel microspheres was recorded, observed and ...
MA Fangfang +6 more
doaj +1 more source
Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells. [PDF]
PLoS ONE, 2014 In vitro and in vivo models are widely used in cancer research. Characterizing the similarities and differences between a patient's tumor and corresponding in vitro and in vivo models is important for understanding the potential clinical relevance of ...
Mehmet Baysan +13 more
doaj +1 more source
Fabrication of 3D Controlled in vitro Microenvironments
MethodsX, 2014 Microfluidics-based lab-on-a-chips have many advantages, one of which is to provide physiologically relevant settings for cell biology experiments. Thus there is an ever increasing interest in their fabrication. Our goal is to construct three dimensional (3D) Controlled in vitro Microenvironments (CivMs) that mimic the in vivo microenvironments.
Berrin Ozdil +3 more
openaire +4 more sources
In Vitro Modeling of the Tumor Microenvironment in Tumor Organoids
Tissue Engineering and Regenerative Medicine, 2020 The tumor microenvironment (TME) represents the many components occupying the space within and surrounding a tumor, including cells, signaling factors, extracellular matrix, and vasculature. Each component has the potential to assume many forms and functions which in turn contribute to the overall state of the TME, and further contribute to the ...
Mahesh, Devarasetty +3 more
openaire +3 more sources
Recent Progress in Microfluidic Models of the Blood-Brain Barrier
Micromachines, 2019 The blood-brain barrier (BBB) is a critical physical and chemical barrier that maintains brain homeostasis. Researchers in academia and industry are highly motivated to develop experimental models that can accurately mimic the physiological ...
Lili Jiang +4 more
doaj +1 more source
3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
Disease Models & Mechanisms, 2017 Even with many advances in treatment over the past decades, cancer still remains a leading cause of death worldwide. Despite the recognized relationship between metastasis and increased mortality rate, surprisingly little is known about the exact ...
Jacob L. Albritton, Jordan S. Miller
doaj +1 more source
Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
Journal of Experimental & Clinical Cancer Research, 2020 The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which modulate several intrinsic TME elements to ...
Somshuvra Bhattacharya +2 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Hematopoietic stem cells (HSCs) provide a life-long supply of haemopoietic cells and are indispensable for clinical transplantation in the treatment of malignant hematological diseases.
Xiaochan Huang +7 more
doaj +1 more source
Breast Cancer Research, 2023 Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity contributes to breast cancer remains unclear.
Rhianna Rachael Romany Blyth +2 more
doaj +1 more source
In vitro microglia models: the era of engineered cell microenvironments
Neural Regeneration Research, 2022 Micro and Nano ...
Sharaf, A.M.S.E. (author) +3 more
openaire +4 more sources