Results 41 to 50 of about 348,397 (157)

“Comparison of in vitro models for the study of senescence of macrophages associated with a tumor

Медицинская иммунология
Tumor-associated macrophages (TAMs) are an important and most represented population of immune cells in the tumor microenvironment. To a great extent, TAMs can determine the direction of the antitumor immune response; they can either additionally ...
T. V. Pukhalskaia, T. R. Yurakova, V. S. Mikhailovskaya, D. A. Bogdanova, O. N. Demidov   +4 more
doaj   +1 more source

Acidic Microenvironment Regulates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating the Generation and Function of Tregs via the PI3K-mTOR Pathway

Frontiers in Immunology, 2020
Hepatic ischemia/reperfusion injury (HIRI) is a major cause of liver dysfunction and even liver failure after liver transplantation and hepatectomy. One of the critical mechanisms that lead to HIRI is an acidic microenvironment, which develops due to the
Xiaojie Gan, Xiaojie Gan, Xiaojie Gan, Xiaojie Gan, Rongsheng Zhang, Rongsheng Zhang, Rongsheng Zhang, Rongsheng Zhang, Jian Gu, Jian Gu, Jian Gu, Jian Gu, Zheng Ju, Zheng Ju, Zheng Ju, Zheng Ju, Xiao Wu, Xiao Wu, Xiao Wu, Xiao Wu, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Hao Peng, Hao Peng, Hao Peng, Hao Peng, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Feng Cheng, Feng Cheng, Feng Cheng, Feng Cheng, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +43 more
doaj   +1 more source

Exploring bone-tumor interactions through 3D in vitro models: Implications for primary and metastatic cancers

Journal of Bone Oncology
Bone tissue serves as a perfect hosting site where metastatic cancer cells of the most prevalent cancer types, such as prostate and breast cancers, as well as the native bone sarcomas, can further proliferate, advancing the disease stage with the ...
Nicolas Cristini, Mohamadreza Tavakoli, Mehdi Sanati, Saber Amin Yavari   +3 more
doaj   +1 more source

Tumor-microenvironment-on-a-chip: the construction and application

Cell Communication and Signaling
Currently, despite the vast amounts of time and money invested in cancer treatment, cancer remains one of the primary threats to human life. The primary factor contributing to the low treatment efficacy is cancer heterogeneity.
Hanzheng Xu, Jiangtao Wen, Jiahua Yang, Shufen Zhou, Yijie Li, Ke Xu, Wei Li, Sen Li   +7 more
doaj   +1 more source

Unlocking the Potential of Stem Cell Microenvironments In Vitro

Bioengineering
The field of regenerative medicine has recently witnessed groundbreaking advancements that hold immense promise for treating a wide range of diseases and injuries. At the forefront of this revolutionary progress are stem cells. Stem cells typically reside in specialized environments in vivo, known as microenvironments or niches, which play critical ...
Chiara Scodellaro, Raquel R. Pina, Frederico Castelo Ferreira, Paola Sanjuan-Alberte, Tiago G. Fernandes   +4 more
openaire   +3 more sources

Impact of hysteroscopic tubal occlusion on the uterine microenvironment and pregnancy outcomes in tubal factor infertility

The Journal of Maternal-Fetal & Neonatal Medicine
Background Hysteroscopic tubal occlusion serves as an effective minimally invasive treatment, aiming to improve the efficacy of assisted reproductive technologies by preventing hydrosalpinx fluid from entering the uterine cavity.
Yiling Cai, Chengrong Wu, Ying Song, Shunfang Wang, Li Sun, Hualei Cai   +5 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio
The hallmarks of cancer extend beyond genetic anomalies to encompass a sophisticated tumor microenvironment, involving interactions between cancer and non‐cancer cells within a dynamic biophysical setting, influencing cancer progression.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
doaj   +1 more source

A Modular Microscale Granuloma Model for Immune-Microenvironment Signaling Studies in vitro

Frontiers in Bioengineering and Biotechnology, 2020
Tuberculosis (TB) is one of the most potent infectious diseases in the world, causing more deaths than any other single infectious agent. TB infection is caused by inhalation of Mycobacterium tuberculosis (Mtb) and subsequent phagocytosis and migration ...
Samuel B. Berry, Maia S. Gower, Xiaojing Su, Chetan Seshadri, Ashleigh B. Theberge, Ashleigh B. Theberge   +5 more
doaj   +1 more source

A promising breakthrough in pancreatic cancer research: The potential of spheroids as 3D models [PDF]

BioImpacts
Pancreatic ductal adenocarcinoma (PDAC) stands as the fourth leading cause of cancer-related deaths, primarily attributable to its resistance to chemotherapy, resulting in a nearly universal fatality rate.
Nazanin Jamshidi, Negar Jamshidi, Amir Modarresi Chahardehi, Elahe Shams, Vahid Chaleshi   +4 more
doaj   +1 more source

Crosslinked Collagenic Scaffold Behavior Evaluation by Physico-Chemical, Mechanical and Biological Assessments in an In Vitro Microenvironment. [PDF]

Polymers (Basel), 2022
Tihăuan BM, Pircalabioru GG, Axinie Bucos M, Marinaș IC, Nicoară AC, Măruțescu L, Oprea O, Matei E, Maier SS.   +8 more
europepmc   +1 more source