Results 61 to 70 of about 348,397 (157)

Adenosine Concentration Determination for in Vitro Tumor Microenvironment Simulation

Dose-Response
Objectives We aimed to investigate the concentration of adenosine (ADO) in the tumor microenvironment (TME), focusing on its potential to modulate tumor cells and natural killer (NK) cells, thereby facilitating tumor immune escape. Methods
Chun Chen, Chuanpeng Yang, Shuning Hu, Wenjie Nie, Sudan Ye, Minghao Lu, Xingjie Xu, Huajun Hu   +7 more
openaire   +3 more sources

Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation

Pharmaceutics
Organ-on-a-chip technology is attracting growing interest across various domains as a crucial platform for drug screening and testing and is set to play a significant role in precision medicine research.
Qi Wang, Yuanzhan Yang, Zixuan Chen, Bo Li, Yumeng Niu, Xiaoqiong Li   +5 more
doaj   +1 more source

Current developments in modelling the tumour microenvironment in vitro

Organs-on-a-Chip, 2021
Tumour cell proliferation, metabolism and treatment response depend on the dynamic interaction of the tumour cells with other cellular components and physicochemical gradients present in the tumour microenvironment. Traditional experimental approaches used to investigate the dynamic tumour tissue face a number of limitations, such as lack of biological
Ahmed, Monieb A. M., Nagelkerke, Anika
openaire   +1 more source

In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation

Frontiers in Genetics
Colorectal cancer (CRC) is a leading global cancer with high mortality, especially in metastatic cases, with limited therapeutic options. The tumor microenvironment (TME), a network comprising various immune cells, stromal cells and extracellular (ECM ...
Veroniaina Hanitrarimalala, Veroniaina Hanitrarimalala, Zdenka Prgomet, Zdenka Prgomet, My Hedhammar, Helena Tassidis, Anette Gjörloff Wingren, Anette Gjörloff Wingren, Anette Gjörloff Wingren   +8 more
doaj   +1 more source

Investigation of sphingolipid-related genes in lung adenocarcinoma

Frontiers in Molecular Biosciences
BackgroundLung adenocarcinoma (LUAD) is responsible for majority cases of lung cancer and considered to be the primary cause of cancer-related mortality.
Jibin Mao, Li Li, Hui Sun, Jie Han, Jinqiao Li, Chang-Sheng Dong, Hongyu Zhao   +6 more
doaj   +1 more source

Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering. [PDF]

J Biol Eng, 2018
Rijal G, Li W.
europepmc   +1 more source

In vitro studies on the hemopoietic microenvironment

In vitro studies on the hemopoietic microenvironment
1982 【要旨】
openaire  

An organotypic human melanoma-in-skin model as an in vitro tool for testing Vγ9Vδ2-T cell-based immunotherapy

Immuno-Oncology and Technology
Background: Despite considerable advancements in cancer immunotherapy, advanced melanoma still presents a substantial clinical challenge. In an effort to explore treatment options, we examined the immunotherapeutic potential of effector Vγ9Vδ2-T cells in 
E. Michielon, L.A. King, T. Waaijman, M. Veth, S.W. Spiekstra, H.J. van der Vliet, S. Gibbs, T.D. de Gruijl   +7 more
doaj   +1 more source

How organ-on-a-chip is advancing cancer research and oncology - a cancer hallmarks’ perspective

Frontiers in Lab on a Chip Technologies
Despite significant improvements in methodologies behind the development of new anticancer therapies, the path from early-stage drug development through preclinical and clinical development pipeline is still arduous.
Leela Rani Avula, Piotr Grodzinski
doaj   +1 more source

A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation

Bioactive Materials
Glioma is an aggressive brain tumor with a poor prognosis. Establishing an in vitro culture model that closely replicates the cellular composition and microenvironment of the original tumor has been challenging, limiting its clinical applications.
Chengjun Zheng, Peng Wang, Delong Zhang, Zheng Fang, Yutong Feng, Jie Chen, Jiahong Chen, Yiwen Fu, Bao Yang, Shuqing Yu, Li Min, Bo Xiao, Cencan Xing, Yang Yang, Jianfeng Wang, Donghua Zou, Shipeng Ning, Tong Liu, Jun Yan, Qian Zhao, Fei Sun, Qiaodong Chen, Ying Zhang, Tao Jiang, Lemin Zheng, Zhaoshi Bao   +25 more
doaj   +1 more source