Results 51 to 60 of about 348,397 (157)

Biomechanical research using advanced micro-nano devices: In-Vitro cell Characterization focus

Journal of Advanced Research
Background: Cells in the body reside in a dynamic microenvironment subjected to various physical stimuli, where mechanical stimulation plays a crucial role in regulating cellular physiological behaviors and functions.
Shiqiang Yan, Yan Lu, Changming An, Wanglai Hu, Yaofeng Chen, Ziwen Li, Wenbo Wei, Zongzheng Chen, Xianhai Zeng, Wei Xu, Zhenghua Lv, Fan Pan, Wei Gao, Yongyan Wu   +13 more
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Bioengineering Models for Breast Cancer Research

Breast Cancer: Basic and Clinical Research, 2015
Despite substantial advances in early diagnosis, breast cancer (BC) still remains a clinical challenge. Most BC models use complex in vivo models and two-dimensional monolayer cultures that do not fully mimic the tumor microenvironment.
Khadidiatou Guiro, Treena L. Arinzeh
doaj   +1 more source

A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2

Journal of Biological Engineering, 2018
Background While hypoxia has been well-studied in various tumor microenvironments, its role in cancer cell dormancy is poorly understood, in part due to a lack of well-established in vitro and in vivo models. Hypoxic conditions under conventional hypoxia
Hak Rae Lee, Faith Leslie, Samira M. Azarin   +2 more
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If Artificial In Vitro Microenvironment Can Influence Tumor Drug Resistance Network via Modulation of lncRNA Expression?-Comparative Analysis of Glioblastoma-Derived Cell Culture Models and Initial Tumors In Vivo. [PDF]

Cell Mol Neurobiol, 2022
Witusik-Perkowska M, Jaskólski DJ, Liberski PP, Szemraj J.   +3 more
europepmc   +1 more source

An in Vitro Microenvironment for Nucleus Pulposus Regeneration

, 2019
Intervertebral disc degeneration begins early in life, increases with age, and can ultimately result in disc failure. At the center of the disc, the nucleus pulposus (NP) resides in a hypoxic environment where degeneration is thought to begin. Initially, nucleus pulposus cells (NPCs) display altered morphology and function, along with increased rates ...
openaire   +2 more sources

Development of an in vitro microenvironment for maturing oocytes

, 2008
The development of in vitro culture systems, comparable to the in vivo microenvironment in terms of effect on the oocyte growth and development could provide a valuable experimental tool for studying the mechanisms governing folliculogenesis.
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Bioengineering The Tumour Microenvironment In Vitro

In solid tumours, cells reside within a highly dynamic and heterogeneous microenvironment shaped by various physicochemical gradients. This environment significantly influences tumour cell behaviour, including metabolism, proliferation, invasion, and therapy response.
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Integrated in vivo and in vitro experiments with multi-omics analysis reveal SPP1 drives pancreatic cancer progression

BMC Cancer
Objective To investigate the expression pattern of SPP1 in pancreatic cancer and its role in the tumor immune microenvironment, with functional validation by in vivo and in vitro experiments.
Mujing Ke
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A spheroid model that recapitulates the protective role of the lymph node microenvironment and serves as a platform for drug testing in chronic lymphocytic leukemia

HemaSphere
Chronic lymphocytic leukemia (CLL) B cells are characterized by a propensity to undergo rapid apoptosis when cultured in vitro, underscoring the importance of the tissue microenvironment for disease survival.
Elisa Lenti, Edoardo Visentin, Engin Bojnik, Alessia Neroni, Martina Franchino, Daniela Talarico, Nicolò Sacchetti, Lydia Scarfò, Aurora Maurizio, Jose Manuel Garcia‐Manteiga, Paolo Ghia, Andrea Brendolan   +11 more
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In vitro phenotypically stable cartilage regeneration with mechanically adaptable microenvironment using a hydrostatic pressure bioreactor

Bioactive Materials
The regenerative repair of diverse cartilage injuries is a remarkable clinical challenge. Recently, hydrogel-based tissue engineering strategy offers an alternative treatment for cartilage defect repair.
Can Qiu, Yanhua Tang, Yunzhe Zhang, Tian An, Xuelan Chen, Shuang He, Zheng Ci, Wei Zhang, Huitang Xia, Yingying Huo, Di Wang, Guangdong Zhou, Yujie Hua   +12 more
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