Results 31 to 40 of about 370,076 (257)
In vitro microglia models: the era of engineered cell microenvironments
Neural Regeneration Research, 2022 Micro and Nano ...
Sharaf, A.M.S.E. (author) +3 more
openaire +4 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
BMC Bioinformatics, 2020 Background Antibodies revolutionized cancer treatment over the past decades. Despite their successfully application, there are still challenges to overcome to improve efficacy, such as the heterogeneous distribution of antibodies within tumors.
Ana Luísa Cartaxo +6 more
doaj +1 more source
Progress in mimicking brain microenvironments to understand and treat neurological disorders
APL Bioengineering, 2021 Neurological disorders including traumatic brain injury, stroke, primary and metastatic brain tumors, and neurodegenerative diseases affect millions of people worldwide. Disease progression is accompanied by changes in the brain microenvironment, but how
Mai T. Ngo, Brendan A. C. Harley
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The tendon microenvironment: Engineered in vitro models to study cellular crosstalk
Advanced Drug Delivery Reviews, 2022 Tendinopathy is a multi-faceted pathology characterized by alterations in tendon microstructure, cellularity and collagen composition. Challenged by the possibility of regenerating pathological or ruptured tendons, the healing mechanisms of this tissue have been widely researched over the past decades.
Gómez-Florit, Manuel +3 more
openaire +3 more sources
“Comparison of in vitro models for the study of senescence of macrophages associated with a tumor
Медицинская иммунологияTumor-associated macrophages (TAMs) are an important and most represented population of immune cells in the tumor microenvironment. To a great extent, TAMs can determine the direction of the antitumor immune response; they can either additionally ...
T. V. Pukhalskaia +4 more
doaj +1 more source
Intestine‐on‐a‐chip for intestinal disease study and pharmacological research
View, 2023 Intestinal diseases seriously affect the quality of life. The assays for intestinal disease study based on two‐dimensional in vitro cell culture and animal models fail to model human physiology and pathophysiology accurately. As a bridge between in vitro
Dongxue Zhang, Liang Qiao
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Advances on the roles of tumor microenvironment in bone cancer pain [PDF]
Jichu yixue yu linchuang, 2021 Tumor microenvironment (TME) is the in vitro microenvironment in which tumors live. Cancer-induced bone pain(CIBP) is one of the most common symptoms of tumor bone metastasis.
ZHOU Jia-hong, LI Min
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