Results 31 to 40 of about 348,397 (157)
Biomimetic Strategies for the Glioblastoma Microenvironment
Frontiers in Materials, 2017 Glioblastoma multiforme (GBM) is a devastating type of tumor with high mortality, caused by extensive infiltration into adjacent tissue and rapid recurrence.
Junghwa Cha, Pilnam Kim
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In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead?
CellsHaematological malignancies comprise a diverse group of life-threatening systemic diseases, including leukaemia, lymphoma, and multiple myeloma. Currently available therapies, including chemotherapy, immunotherapy, and CAR-T cells, are often associated ...
Carlotta Mattioda +3 more
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HeliyonBrain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is the difficulty in emulating the ...
Richu Raju R +2 more
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BMC Bioinformatics, 2020 Background Antibodies revolutionized cancer treatment over the past decades. Despite their successfully application, there are still challenges to overcome to improve efficacy, such as the heterogeneous distribution of antibodies within tumors.
Ana Luísa Cartaxo +6 more
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Progress in mimicking brain microenvironments to understand and treat neurological disorders
APL Bioengineering, 2021 Neurological disorders including traumatic brain injury, stroke, primary and metastatic brain tumors, and neurodegenerative diseases affect millions of people worldwide. Disease progression is accompanied by changes in the brain microenvironment, but how
Mai T. Ngo, Brendan A. C. Harley
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Intestine‐on‐a‐chip for intestinal disease study and pharmacological research
View, 2023 Intestinal diseases seriously affect the quality of life. The assays for intestinal disease study based on two‐dimensional in vitro cell culture and animal models fail to model human physiology and pathophysiology accurately. As a bridge between in vitro
Dongxue Zhang, Liang Qiao
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Tumor Microenvironment – Possibilities of the Research Under In Vitro Conditions [PDF]
Klinicka onkologie, 2014 Tumorigenesis is always accompanied by alterations of the microenvironment in the respective tissue. The tumor microenvironment represents a heterogeneous complex, in which cell proliferation, differentiation, necrosis or apoptosis are regulated by various extracellular stimuli, and it can also lead to development of an aggressive phenotype of tumor ...
P, Chlapek +3 more
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The tendon microenvironment: Engineered in vitro models to study cellular crosstalk
Advanced Drug Delivery Reviews, 2022 Tendinopathy is a multi-faceted pathology characterized by alterations in tendon microstructure, cellularity and collagen composition. Challenged by the possibility of regenerating pathological or ruptured tendons, the healing mechanisms of this tissue have been widely researched over the past decades.
Gómez-Florit, Manuel +3 more
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Advances on the roles of tumor microenvironment in bone cancer pain [PDF]
Jichu yixue yu linchuang, 2021 Tumor microenvironment (TME) is the in vitro microenvironment in which tumors live. Cancer-induced bone pain(CIBP) is one of the most common symptoms of tumor bone metastasis.
ZHOU Jia-hong, LI Min
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Frontiers in Oncology, 2023 Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies nowadays. The available chemo- and immunotherapies are often ineffective in treating PDAC due to its immunosuppressive and highly desmoplastic tumor immune microenvironment ...
Giulio Giustarini +5 more
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