Results 11 to 20 of about 348,397 (157)
Modeling Tumor Microenvironments In Vitro [PDF]
Journal of Biomechanical Engineering, 2014 Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and blood and lymphatic vessels.
Mingming Wu, Melody A. Swartz
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Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models
Cells, 2021 Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects cancer progression, metastasis and metabolism. Oxygen induces both proteomic and genomic changes within tumor cells, which cause many alternations in the tumor ...
Iwona Ziółkowska-Suchanek
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Behaviors of Glioblastoma Cells in in Vitro Microenvironments [PDF]
Scientific Reports, 2019 AbstractGlioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus ...
Wenwen Diao +11 more
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Tumor heterogeneity: preclinical models, emerging technologies, and future applications
Frontiers in Oncology, 2023 Heterogeneity describes the differences among cancer cells within and between tumors. It refers to cancer cells describing variations in morphology, transcriptional profiles, metabolism, and metastatic potential. More recently, the field has included the
Marco Proietto +14 more
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Microenvironment Influences on Human Umbilical Cord Mesenchymal Stem Cell-Based Bone Regeneration
Stem Cells International, 2021 The microenvironment, or niche, regulates stem cell fate and improves differentiation efficiency. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are ideal cell source for bone tissue engineering.
Lingling E +11 more
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Hydrogels to engineer tumor microenvironmentsin vitro
Biomaterials Science, 2021 Illustration of engineered hydrogel to recapitulate aspects of the tumor microenvironment.
Kanishka Fernando +3 more
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Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine
Micromachines, 2021 The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in
Jisoo Kim, Jinah Jang, Dong-Woo Cho
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Transplantation of mouse iPSCs into testis of azoospermic mouse model: in vivo and in vitro study
Artificial Cells, Nanomedicine, and Biotechnology, 2019 This study aimed to induce spermatogenesis in azoospermic testis through induced pluripotent stem cells (iPSCs) derived spermatogonial stem cell-like cells (SSCLCs) after iPSCs in vivo and in vitro transplantation and three-dimensional organ culture. DiI-
Forouzan Rahmani +3 more
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Application of microfluidic chips in the simulation of the urinary system microenvironment
Materials Today Bio, 2023 The urinary system, comprising the kidneys, ureters, bladder, and urethra, has a unique mechanical and fluid microenvironment, which is essential to the urinary system growth and development.
Changhao Hou +9 more
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Improving Bioprinted Volumetric Tumor Microenvironments In Vitro
Trends in Cancer, 2020 Despite the great breakthroughs in the past few decades in illuminating the pathological mechanisms of cancer and in developing new anticancer drugs, it remains extremely challenging to cure most cancers. Therefore, it is imperative to develop more sophisticated and more biomimetic preclinical cancer models.
Jun Li +3 more
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