Results 11 to 20 of about 370,076 (257)
Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment. [PDF]
PLoS ONE, 2018 Vasculature is an interface between the circulation and the hematopoietic tissue providing the means for hundreds of billions of blood cells to enter the circulation every day in a regulated fashion.
Surya Kotha +10 more
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Effect of Mechanical Microenvironment on Collagen Self-Assembly In Vitro
Journal of Functional Biomaterials, 2023 Collagen, as a structural protein, is widely distributed in the human body. Many factors influence collagen self-assembly in vitro, including physical-chemical conditions and mechanical microenvironment, and play a key role in driving the structure and ...
Leihan Han +5 more
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New Frontiers in modeling the lipedema microenvironment in vitro
Frontiers in Cell and Developmental BiologyLipedema is a chronic and often debilitating adipose tissue disorder that primarily affects women. The disease is characterized by disproportionate and symmetrical accumulation of subcutaneous fat in the extremities.
Khushi Soni, Rosalyn D. Abbott
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Modeling Tumor Microenvironments In Vitro [PDF]
Journal of Biomechanical Engineering, 2014 Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and blood and lymphatic vessels.
Mingming Wu, Melody A. Swartz
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Behaviors of Glioblastoma Cells in in Vitro Microenvironments [PDF]
Scientific Reports, 2019 AbstractGlioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus ...
Wenwen Diao +11 more
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Hydrogels to engineer tumor microenvironments in vitro
Biomaterials Science, 2021 Illustration of engineered hydrogel to recapitulate aspects of the tumor microenvironment.
Kanishka Fernando +3 more
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Improving Bioprinted Volumetric Tumor Microenvironments In Vitro
Trends in Cancer, 2020 Despite the great breakthroughs in the past few decades in illuminating the pathological mechanisms of cancer and in developing new anticancer drugs, it remains extremely challenging to cure most cancers. Therefore, it is imperative to develop more sophisticated and more biomimetic preclinical cancer models.
Jun Li +3 more
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Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
Journal of Experimental & Clinical Cancer Research, 2020 The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which modulate several intrinsic TME elements to ...
Somshuvra Bhattacharya +2 more
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Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To establish an in vitro culture model mimicking tumor microenvironment using hydrogel microspheres and fresh primary pancreatic cancer cells.Methods·The morphological distribution of the hydrogel microspheres was recorded, observed and ...
MA Fangfang +6 more
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Recent Progress in Microfluidic Models of the Blood-Brain Barrier
Micromachines, 2019 The blood-brain barrier (BBB) is a critical physical and chemical barrier that maintains brain homeostasis. Researchers in academia and industry are highly motivated to develop experimental models that can accurately mimic the physiological ...
Lili Jiang +4 more
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