Results 81 to 90 of about 608,878 (283)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Nonlinear Fredholm equations in modular function spaces
Electronic Journal of Differential Equations, 2019 We investigate the existence of solutions in modular function spaces of the Fredholm integral equation $$ \Phi(\theta) = g(\theta) + \int^1_0 f(\theta,\sigma, \Phi(\sigma)) \,d\sigma, $$ where $\Phi(\theta), g(\theta)\in L_{\rho}, \theta\in [0,1 ...
Mostafa Bachar
doaj
On the zeros of certain modular functions for the normalizers of congruence subgroups of low levels I [PDF]
, 2008 Junichi Shigezumi
openalex +1 more source
$p$-Adic hypergeometric functions in the connections with certain twisted Kloosterman sheaf sum and modular forms [PDF]
, 2020 Neelam Saikia
openalex +1 more source
Central Values of Degree Six L-functions: The Case of Hilbert Modular Forms [PDF]
, 2021 Utkarsh Agrawal
openalex +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Semigroups and Evolution Equations in Modular Function Spaces
AxiomsThis paper develops the theory of strongly continuous semigroups and abstract evolution equations in modular function spaces. We study the autonomous problem u˙(t)=Bu(t) with initial condition u(0)=u0∈Lρ, where B is the infinitesimal generator of a ...
Mostafa Bachar
doaj +1 more source
A nature inspired modularity function for unsupervised learning involving spatially embedded networks [PDF]
, 2019 Raj Kishore +3 more
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source