Results 11 to 20 of about 1,338 (199)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The characters and structure of a class of modular representation algebras of cyclic p-groups [PDF]
Journal of the Australian Mathematical Society, 1978 AbstractLet p,m be the modular representation algebra of the cyclic group of order pm over the prime field Zp. The characters of p, m are derived. For p = 2, this provides an alternative proof of a result due to Carlson (1975), tha 2,m is a local ring. It is shown that for p>2, p, m is a direct sum of 2m local rings.
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Universal sectors of two-dimensional Carrollian CFTs
Journal of High Energy PhysicsWe revisit modular invariance in two-dimensional Carrollian conformal field theories from a geometric perspective. Focusing on the characters of the induced and highest-weight representations of the theory, we show that there are regions of parameter ...
Ankit Aggarwal +5 more
doaj +1 more source
Modular representations in type A with a two-row nilpotent central character
Journal of AlgebraRevised version, examples ...
Dobrovolska, Galyna +2 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Machine Learning: Science and TechnologyAutomated exploration of chemical space through machine learning has become a central strategy in modern drug discovery, where the ability to learn transferable molecular representations directly impacts predictive modeling performance.
Neerav Kaushal, Ajay M N V Penmatsa
doaj +1 more source
Central Characters for Smooth Irreducible Modular Representations of GL$_2$ ($Q_p$)
Rendiconti del Seminario Matematico della Università di Padova, 2012 We prove that every smooth irreducible F_p -linear representation of GL _2 ( Q_p )
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