Results 31 to 40 of about 1,857 (223)

Modular representations in type A with a two-row nilpotent central character

open access: yesJournal of Algebra
Revised version, examples ...
Dobrovolska, Galyna   +2 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

On the structure of Foulkes modules for the symmetric group [PDF]

open access: yes, 2015
This thesis concerns the structure of Foulkes modules for the symmetric group. We study `ordinary' Foulkes modules $H^{(m^n)}$, where $m$ and $n$ are natural numbers, which are permutation modules arising from the action on cosets of $\mathfrak{S}_m\wr ...
de Boeck, Melanie
core  

FragBERTa: a fragment-aware molecular representation model with sequential attachment-based fragment embeddings

open access: yesMachine Learning: Science and Technology
Automated exploration of chemical space through machine learning has become a central strategy in modern drug discovery, where the ability to learn transferable molecular representations directly impacts predictive modeling performance.
Neerav Kaushal, Ajay M N V Penmatsa
doaj   +1 more source

Central Characters for Smooth Irreducible Modular Representations of GL$_2$ ($Q_p$)

open access: yesRendiconti del Seminario Matematico della Università di Padova, 2012
We prove that every smooth irreducible F_p -linear representation of GL _2 ( Q_p )
openaire   +4 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Modular spin characters of symmetric groups [PDF]

open access: yes, 2012
The dissertation is concerned with concrete computations of modular spin characters of symmetric and alternating groups. We calculate all irreducible p-modular spin characters of the symmetric group Sym(n) and the alternating group Alt(n) for n=14,..,18 ...
Maas, Lukas Alexander
core  

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