Results 31 to 40 of about 1,522 (244)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The modular characters of the Higman-Sims simple group
, 1982 SynopsisIn this article the Brauer characters of the irreducible p-modular representations of the Higman-Sims simple group of order 44352000 are determined when p is an odd prime.
J. F. Humphreys
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Density of classical points in eigenvarieties [PDF]
, 2011 In this short note, we study the geometry of the eigenvariety parametrizing p-adic automorphic forms for GL(1) over a number field, as constructed by Buzzard. We show that if K is not totally real and contains no CM subfield, points in this space arising
Loeffler, David
core
On the character of certain modular irreducible representations
, 2014 6 ...
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Endotrivial modules for finite groups of Lie type. [PDF]
, 2006 We classify the endotrivial modules for all finite groups of Lie type in defining ...
Mazza, Nadia +2 more
core
Higher-Level Appell Functions, Modular Transformations, and Characters
, 2005 We study modular transformation properties of a class of indefinite theta series involved in characters of infinite-dimensional Lie superalgebras. The level- Appell functions satisfy open quasiperiodicity relations with additive theta-function terms ...
A.M. Semikhatov +5 more
core +1 more source