Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The characters and structure of a class of modular representation algebras of cyclic p-groups [PDF]
AbstractLet p,m be the modular representation algebra of the cyclic group of order pm over the prime field Zp. The characters of p, m are derived. For p = 2, this provides an alternative proof of a result due to Carlson (1975), tha 2,m is a local ring. It is shown that for p>2, p, m is a direct sum of 2m local rings.
openaire +2 more sources
Modular transformations of admissible N = 2 and Affine sl(2|1;C) characters [PDF]
This thesis is a study of the affine super-algebra sl(2|l; C) and N = 2 superconformal algebra at fractional levels. In the first chapter we review background material on Conformal Field Theory, and how it appears in the context of string theory and the ...
Sadeghi, Jafar
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Aspects of the affine superalgebra sl(2|1) at fractional level [PDF]
Aspects of the Affine Superalgebra sl(2|l) at Fractional Level Ph.D. Thesis by Gavin Balfour Johnstone, April 2001 In this thesis we study the affine superalgebra sl(2|l; C) at fractional levels of the form k = l/u-l,uєN\{l}.
Johnstone, Gavin Balfour +1 more
core
Universal sectors of two-dimensional Carrollian CFTs
We revisit modular invariance in two-dimensional Carrollian conformal field theories from a geometric perspective. Focusing on the characters of the induced and highest-weight representations of the theory, we show that there are regions of parameter ...
Ankit Aggarwal +5 more
doaj +1 more source
Modular representations in type A with a two-row nilpotent central character
Revised version, examples ...
Dobrovolska, Galyna +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On the structure of Foulkes modules for the symmetric group [PDF]
This thesis concerns the structure of Foulkes modules for the symmetric group. We study `ordinary' Foulkes modules $H^{(m^n)}$, where $m$ and $n$ are natural numbers, which are permutation modules arising from the action on cosets of $\mathfrak{S}_m\wr ...
de Boeck, Melanie
core
Central Characters for Smooth Irreducible Modular Representations of GL$_2$ ($Q_p$)
We prove that every smooth irreducible F_p -linear representation of GL _2 ( Q_p )
openaire +4 more sources

