Results 41 to 50 of about 39,216 (213)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Modular generalized Springer correspondence: an overview [PDF]
, 2016 This is an overview of our series of papers on the modular generalized Springer correspondence. It is an expansion of a lecture given by the second author in the Fifth Conference of the Tsinghua Sanya International Mathematics Forum, Sanya, December 2014,
Achar, Pramod N. +3 more
core
Ordinary pseudorepresentations and modular forms
, 2017 In this short note, we observe that the techniques of our recent work "Pseudo-modularity and Iwasawa theory" can be used to provide a new proof of some of the residually reducible modularity lifting results of Skinner and Wiles.
Wake, Preston, Wang-Erickson, Carl
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Multiplicity one for certain paramodular forms of genus two
, 2017 We show that certain paramodular cuspidal automorphic irreducible representations of $\mathrm{GSp}(4,\mathbb{A}_\mathbb{Q})$, which are not CAP, are globally generic.
Rösner, Mirko, Weissauer, Rainer
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A Unified Scheme for Modular Invariant Partition Functions of WZW Models
, 1993 We introuduce a unified method which can be applied to any WZW model at arbitrary level to search systematically for modular invariant physical partition functions.
Abolhassani, M. R., Ardalan, F.
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source