Results 151 to 160 of about 59,609 (323)

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Synthetic Biology:Constructing Nature? [PDF]

, 2010
Ankeny R. a., Arkin A., Arkin A.P., Balaram P., Ball P., Barnes S.B., Barrett C.L., Biagioli M., Braun B., Breithaupt H., Brent R., Calvert J., Cello J., Conley J.M., De Vriend H., Deamer D., Dueber J.E., Dupré J., Dutfield G., Elowitz M.B., Endy D., Endy D., Ferber D., Franklin S., Franklin S., Gallivan J.P., Glass J. I., Hacking I., Hartwell L.H., Heinemann M., Isaacs F.J., Jane Calvert, Jasanoff S., Keasling J.D., Keller E.F., Kevles D.J., Kitano H., Kohler R.E., Lazebnik Y., Lentzos F., Loettgers A., Luisi P.L., Marcus G.E., Martin V.J.J., Morange M., NEST, O'Malley M. A., Oliver S., Palsson B., Pottage A., Pottage A., Pottage A., Rabinow P., Rheinberger H-J., Royal Academy of Engineering, Sauro H.M., Silver P., Tucker J.B., Villalobos A., Weiss R., Wilmut I., Wimsatt W.   +61 more
core   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Developing covalent affinity-based probes and inhibitors for sialyltransferases using a modular and direct-to-biology compatible chlorotriazine (ClTriZ) warhead platform [PDF]

Jun Yang Ong, E. Meléndez, Tom Wennekes
openalex   +1 more source

Integrated phenotypes:understanding trait covariation in plants and animals [PDF]

, 2014
Armbruster, Scott, Bolstad, Geir H., Hansen, Thomas F., Pelabon, Christophe   +3 more
core   +1 more source

Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach

European Journal of Medical Research
Background Chronic kidney disease presents global health challenges, with hemodialysis as a common treatment. However, non-dialyzable uremic toxins demand further investigation for new therapeutic approaches.
Roya Asadi, Pejman Shadpour, Akram Nakhaei   +2 more
doaj   +1 more source

Smart Face Masks as Wearable Respiratory Sensors: A Review of Sensor Technologies, Materials, and Future Directions

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in smart face masks that actively monitor breathing. By integrating humidity, gas, temperature, pressure, strain, and triboelectric sensors, these masks track key respiratory parameters in real time. The article summarizes sensor mechanisms, compares performance across studies, and discusses challenges and future ...
Negin Faramarzi, Naseeh Backer Kannanthodi, Alice Nicole Casling, Babar Ali, Samira Lakouraj Mansouri, Alessandro Giuseppe D'aloia, Hossein Cheraghi Bidsorkhi, Maria Sabrina Sarto   +7 more
wiley   +1 more source