Results 171 to 180 of about 59,609 (323)

Advancements in synthetic biology-based bacterial cancer therapy: A modular design approach

, 2023
Andrés Arboleda-García, Iván Alarcon‐Ruiz, Lissette Boada-Acosta, Yadira Boada, Alejandro Vignoni, Eloísa Jantus‐Lewintre   +5 more
openalex   +1 more source

Systems Biology Approaches to Evaluate Disease Modularity

, 2014
Biological systems are in a constant process of innovation as an essential precondition to evolve. For this reason, the emergence of phenotypic variation is an inherent property of complex adaptive systems. Even though living systems acquire robustness to internal and external disturbances during the evolutionary process, pathological conditions entail
openaire   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Modular languages for systems and synthetic biology

, 2010
Systems biology is a rapidly growing field which seeks a refined quantitative understanding of organisms, particularly studying how molecular species such as metabolites, proteins and genes interact in cells to form the complex emerging behaviour exhibited by living systems.
openaire   +1 more source

Modularity Emerges from Action-Functional Constraints in Marine Metabolic Networks: A Biology-Scale Validation of the Network-Weighted Action Principle [PDF]

Martin G. Frasch
openalex   +2 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Topology-aware design of spiking neural networks via modular graph architectures. [PDF]

PLoS One
Motaghian F, Nazari S, Dominguez-Morales JP, Jafari R.   +3 more
europepmc   +1 more source

Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release

Advanced Healthcare Materials, EarlyView.
A fundamental mechanism for the simultaneous control of multiple magnetic valves is reported in a miniature soft robotic patch for intravesical drug delivery, enabling fully wireless and programmable liquid release. Integrated with a bioadhesive interface and induction‐coupling‐based liquid volume sensing, the soft robotic patch is promising to enable ...
Boyang Xiao, Yi Zhu, Yusheng Wang, Janene M. Pierce, Jeffrey J. Tosoian, Xiaoguang Dong   +5 more
wiley   +1 more source

Organizational Principles of Biological Systems. [PDF]

Biology (Basel)
Navarro-Quiroz RC, Navarro Quiroz K, Navarro Quiroz V, Gabucio A, Fernández-Cisnal R, Geribaldi-Doldán N, Fernandez-Ponce C, Gomar IS, Bello Lemus Y, Zárate Peñata E, Pacheco-Lugo LA, Londoño-Pacheco LC, Rebolledo Cobos M, Acosta Hoyos A, Pava Garzon D, Camacho JLV, Navarro Quiroz E.   +16 more
europepmc   +1 more source