Results 111 to 120 of about 776,397 (353)

Waveguide Engineering of Graphene Optoelectronics—Modulators and Polarizers

IEEE Photonics Journal, 2018
The concept of incorporating graphene into nanophotonic waveguides has pullulated into massive broadband optoelectronic applications with compact footprint.
Yuan Meng, Shengwei Ye, Yijie Shen, Qirong Xiao, Xing Fu, Rongguo Lu, Yong Liu, Mali Gong   +7 more
doaj   +1 more source

Heterodyne Holography with full control of both signal and reference arms

, 2015
Heterodyne holography is a variant of phase shifting holography in which reference and signal arms are controlled by acousto optic modulators. In this review paper, we will briefy describe the method and its properties, and we will illustrate its ...
Gross, Michel
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Drivers and modulators in the central auditory pathways

Frontiers in Neuroscience, 2010
The classic view of auditory information flow depicts a simple serial route from the periphery through tonotopically-organized nuclei in the brainstem, midbrain and thalamus, ascending eventually to the neocortex.
Charles C Lee, S. M Sherman
doaj   +1 more source

Modulator Therapy for Cystic Fibrosis: An Exploration of Current Research [PDF]

, 2020
Developing a drug therapy that addresses the root cause of cystic fibrosis (CF) by increasing CFTR protein levels has long been a research challenge. After genetic therapy failed because a suitable delivery system could not be found, researchers began ...
Rombocos, Jessalyn
core   +1 more source

Sirtuin Modulators [PDF]

, 2011
Members of the sirtuin family including the founding protein Sir2 in Saccharomyces cerevisiae have been linked to lifespan extension in simple organisms. This finding prompted evaluation of the role of Sir2 orthologues in many aging-associated conditions including neurodegeneration, type II diabetes and cancer.
Sumit S, Mahajan, Vid, Leko, Julian A, Simon, Antonio, Bedalov   +3 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Modulating antibody N-glycosylation through feed additives using a multi-tiered approach

Frontiers in Bioengineering and Biotechnology
Glycosylation of recombinant proteins is a post-translational modification that affects multiple physicochemical and biological properties of proteins.
Jaka Kranjc, Lovro Kramer, Miha Mikelj, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +5 more
doaj   +1 more source

Glicoproteína-P, resistência a múltiplas drogas (MDR) e relação estrutura-atividade de moduladores P-glycoprotein and multidrug resistance: structure-activity relationships of modulators

Química Nova, 2010
Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity.
Paula C. Huber, Cintia H. Maruiama, Wanda P. Almeida   +2 more
doaj   +1 more source