The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2 [PDF]
, 2009 Jeffrey M. Friedman +7 more
openalex +1 more source
Information and Computation, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kupferman, Orna +2 more
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
8x14Gb/s ring WDM modulator array with integrated tungsten heaters and Ge monitor photodetectors [PDF]
, 2014 An 8x14Gb/s wavelength-division multiplexed Si ring modulator array is presented with uniform channel performance. Tungsten heaters and Ge monitor photodetectors at the ring modulator drop ports are co-integrated to track and control the modulation ...
Absil, P +9 more
core
Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life [PDF]
, 2019 Kevin O. Saunders
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Ultra-High Electro-Optic Activity Demonstrated in a Silicon-Organic Hybrid (SOH) Modulator
, 2018 Efficient electro-optic (EO) modulators crucially rely on advanced materials that exhibit strong electro-optic activity and that can be integrated into high-speed and efficient phase shifter structures.
Blaicher, Matthias +11 more
core +1 more source
The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator [PDF]
, 2001 Angela F. Dulhunty +4 more
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Journal of Algebra, 2012 We study the class of ADS rings and modules introduced by Fuchs. We give some connections between this notion and classical notions such as injectivity and quasi-continuity. A simple ring R such that R is ADS as a right R-module must be either right self-injective or indecomposable as a right R-module. Under certain conditions we can construct a unique
Alahmadi, Adel +2 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source