Results 121 to 130 of about 271,149 (318)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Photonic Tensor Cores: A Comprehensive Review on System Architecture and Device Design
IEEE AccessHighly efficient parallel processing of photonic tensor cores is required for on-chip implementation of photonic neuromorphic algorithms. These photonic tensor cores are realized using interference-based mesh architectures, the unit block of which ...
Md Nabil Shehtab Dhrubo
doaj +1 more source
Optical Transmitters without Driver Amplifiers—Optimal Operation Conditions
Applied Sciences, 2018 An important challenge in optical communications is the generation of highest-quality waveforms with a Mach–Zehnder modulator with a limited electrical swing (Vpp).
Arne Josten +4 more
doaj +1 more source
, 2012 The present approaches on predicting stability of delta-sigma (Δ-Σ) modulators are mostly confined to DC inputs. This poses limitations as practical applications of Δ-Σ modulators involve a wide range of signals other than DC such as multiple-sinusoidal ...
Lota, J., Kale, I., Al-Janabi, M.
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Intensity dependent residual amplitude modulation in electro-optic phase modulators
, 2012 Residual amplitude modulation (RAM) mechanisms in electro-optic phase modulators are detrimental in applications that require high purity phase modulation of the incident laser beam.
Jaatinen, Esa, Sathian, Juna
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Polynomial Modules Over Macaulay Modules [PDF]
Canadian Mathematical Bulletin, 1976 In [2] we introduced a concept of a Macaulay module over a right noetherian ring by saying that all associated primes of the module have the same codimension. That is to say that a module M over a right noetherian ring R is Macaulay if K dim R/P = K dim R/Q for all P, Q ∈ Ass M.
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source