Results 81 to 90 of about 766,195 (336)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Sol-Gel Material-Enabled Electro-Optic Polymer Modulators
Sensors, 2015 Sol-gels are an important material class, as they provide easy modification of material properties, good processability and are easy to synthesize. In general, an electro-optic (EO) modulator transforms an electrical signal into an optical signal.
Roland Himmelhuber +3 more
doaj +1 more source
Journal of Commutative Algebra, 2014 We introduce and study "quasidualizing" modules. An artinian R-module T is quasidualizing if the homothety map \hat R\rightarrow Hom(T,T) is an isomorphism and Ext_R^i(T,T)=0 for each integer i>0. Quasidualizing modules are associated to semidualizing modules via Matlis duality.
openaire +3 more sources
The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]
, 2013 The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves +3 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Demonstratio Mathematica, 2016 AbstractIn this paper, we provide some characterizations of semisimple rings, right V-rings, right hereditary and regular right FGC-rings in terms of C3-modules. The notions of C3-envelope and C3-cover are introduced.
Atani Shahabaddin Ebrahimi +2 more
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A describing function study of saturated quantization and its application to the stability analysis of multi-bit sigma delta modulators [PDF]
, 2013 Just as their single-bit counterparts, multi-bit sigma delta modulators exhibit nonlinear behavior due to the presence of the quantizer in the loop. In the multi-bit case this is caused by the fact that any quantizer has a limited output range and hence ...
De Bock, Maarten +3 more
core +1 more source