Results 141 to 150 of about 1,019,672 (318)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

PENGEMBANGAN E-MODULE BERBASIS PAGEFLIP BOOK BERBANTUAN APLIKASI CANVA GUNA MENINGKATKAN MINAT BELAJAR DAN PENGUASAAN MATERI FISIKA PESERTA DIDIK SMA [PDF]

open access: yes
Penelitian ini bertujuan untuk : (1) menghasilkan e-module berbasis pageflip book berbantuan aplikasi canva yang layak untuk pembelajaran guna meningkatkan minat belajar dan penguasaan materi fisika peserta didik SMA; (2) mengetahui minat belajar dan ...
Bella, Alya Nurfita, Pujianto, Pujianto
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Observation of logic states of HfO2-based ferroelectric FETs using STEM-DPC [PDF]

open access: yesBIO Web of Conferences
Nemec Thorgund   +6 more
doaj   +1 more source

Modulating Modulation [PDF]

open access: yesThe Journal of General Physiology, 2000
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

LES ENFANTS SAUVAGES ET LA QUESTION DE LA NATURE HUMAINE (Wild Children and the Question of Human Nature)

open access: yesOstium, 2018
In the present text, the authors deals with the specific phenomenon of the so-called wild children, i. e. human beings deprived of contact with other members of the human species. We concentrate on a particular historical case – Victor of Aveyron, a wild
Josef Fulka
doaj  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Legal position of the European Central Bank in contemporary social discourse

open access: yesPravo
This paper analyzes the legal position of the European Central Bank (ECB) within the context of contemporary social conditions, focusing on the ECB’s tendency to expand its competencies and the judicial evaluation of the current monetary legislation in ...
Marko Dimitrijević
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

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