Results 11 to 20 of about 23,263 (212)

Glycemic and Renal Effects of SGLT2 Inhibitors in Monogenic Diabetes: A Real-World National Study. [PDF]

Diabetes Obes Metab
ABSTRACT Aims Evidence regarding the efficacy and safety of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in monogenic diabetes is limited. We evaluated real‐world metabolic, renal, and safety outcomes of SGLT2i therapy in adults with monogenic diabetes.
Audrain E, Bel Lassen P, Bellanné-Chantelot C, Vantyghem MC, Dupuis H, Vidal-Trecan T, Chevalier N, Dubois-Laforgue D, Lamothe S, Vatier C, Villard O, Valéro R, Briet C, Vigouroux C, Ciangura C, Amouyal C.   +15 more
europepmc   +2 more sources

O semeynoy forme sakharnogo diabeta 2 tipa u molodykh (MODY) [PDF]

Сахарный диабет, 1999
MODY - это гетерогенный подтип сахарного диабета (СД), характеризующийся ранним дебютом (до 25 лет), аутосомно-доминантным наследованием и первичным дефектом секреции инсулина.
Tatiana Vasil'evna Nikonova, A Yu Garibashvili, Olga Mikhailovna Smirnova, M N Boldyreva, L P Alekseev, Ivan Ivanovich Dedov   +5 more
doaj   +2 more sources

A case of maturity-onset diabetes of the young with a pathogenic HNF1A variant and a coexisting NEUROD1 variant. [PDF]

J Diabetes Investig
ABSTRACT Aims/Introduction Maturity‐onset diabetes of the young (MODY) accounts for at least 1%–5% of diabetes cases and is usually caused by single gene variants. Accurate diagnosis of MODY is important for effective management, especially in young individuals who are lean and lack islet autoantibodies.
Takayoshi T, Hirota Y, Sugawara K, Sugano A, Ohta M, Takeuchi T, Yamamoto A, Satake W, Takaoka Y, Ogawa W.   +9 more
europepmc   +2 more sources

Quality of life assessment in patients with HNF1A-MODY and GCK-MODY [PDF]

Endocrine, 2018
Abstract Aim The impact of maturity onset diabetes of the young (MODY) on quality of life (QoL) has never been examined. We assessed disease impact on QoL among patients with HNF1A-MODY and GCK mutation carrier status. Methods The study included 80 patients with HNF1A-MODY
Magdalena Szopa, Bartlomiej Matejko, Damian Ucieklak, Agata Uchman, Jerzy Hohendorff, Sandra Mrozińska, Wojciech Głodzik, Barbara Zapała, Teresa Płatek, Iwona Solecka, Cyrus M Sani, Maciej T. Małecki   +11 more
openaire   +5 more sources

Fotografie mody. Propozycja typologii

Przeglad Socjologii Jakosciowej
W artykule podjęto kwestię braku typologii fotografii mody. Autor wskazuje na wieloaspektowość nie tylko samego fenomenu mody i jego interpretacji we współczesnym dyskursie naukowym, ale również na szeroki wachlarz praktyk fotograficznych ...
Wojciech Sternak
doaj   +2 more sources

MODY: Strategies for a unique form of diabetes

Journal of Education and Health Promotion
Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj   +2 more sources

Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes [PDF]

Frontiers in Endocrinology
IntroductionMaturity Onset Diabetes of the Young (MODY) remains an underdiagnosed condition with remarkable genetic variability across populations. While diagnostic tools are based on Caucasian cohorts, Whole Exome Sequencing (WES) studies are needed to ...
Alberto Moscona-Nissan, Daniel Marrero-Rodríguez, Sergio Andonegui-Elguera, Eduardo Salif Luna-Ávila, Florencia Martínez-Mendoza, Sandra Vela-Patiño, Itzel Ramírez-Ramos, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Rocio A. Chavez-Santoscoy, Sophia Mercado-Medrez, Kapy S. León-Wu, Regina De Miguel-Ibáñez, Moisés Mercado, Keiko Taniguchi-Ponciano, Aldo Ferreira-Hermosillo   +15 more
doaj   +2 more sources

When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes [PDF]

The Review of Diabetic Studies, 2015
The genomics revolution has raised more questions than it has provided answers. Big data from large population-scale resequencing studies are increasingly deconstructing classic notions of Mendelian disease genetics, which support a simplistic correlation between mutational severity and phenotypic outcome.
Althari, S, Gloyn, A
openaire   +5 more sources

Circulating CD36 is reduced in HNF1A-MODY carriers. [PDF]

PLoS ONE, 2013
INTRODUCTION: Premature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset diabetes of the young (MODY) accounts for approximately 2% of all diabetes, with mutations in the transcription factor ...
Siobhan Bacon, Ma P Kyithar, Jasmin Schmid, Andre Costa Pozza, Aase Handberg, Maria M Byrne   +5 more
doaj   +2 more sources

Prediction of maturity-onset diabetes of the young subtypes using machine learning [PDF]

Frontiers in Digital Health
IntroductionMaturity-onset diabetes of the young (MODY) is a monogenic type of diabetes caused by different pathogenic genetic variants in glucose metabolism-related genes, with GCK-MODY and HFN1A-MODY subtypes being the most frequent.
Israel Figueroa, Israel Figueroa, Ricardo Flores, Andrea Millán, Alejandro de Dios, Gustavo Daniel Frechtel, Ariel Pablo López, Ariel Pablo López, Daniela Mennickent   +8 more
doaj   +2 more sources