Results 71 to 80 of about 23,962 (219)

Environmental Education and Science Teaching in the Context of a Waldorf School: The Use of a Collective Reading Activity to Reflect on Pesticides

School Science and Mathematics, EarlyView.
ABSTRACT The contemporary significance of Scientific Literacy underscores the importance of reading and writing practices, often neglected in classroom settings. The urgent global climate crisis calls for immediate action in Environmental Education, emphasizing holistic environmental relationships.
Karine Fernandes, Cristiano B. Moura, Mateus Salomão Rodrigues Costa   +2 more
wiley   +1 more source

Prevalence of Obesity and Dyslipidemia in Maturity Onset Diabetes of the Young Patients

Endocrinology Research and Practice
Objective: Maturity-onset diabetes of the young (MODY) is an uncommon type of diabetes distinct from type 1 and type 2 diabetes. Diagnosis often depends on clinical suspicion, and misdiagnosis may lead to inappropriate treatment.
Murat Calapkulu, İlknur Öztürk Ünsal, Muhammed Erkam Sencar, Davut Sakiz, Mustafa Ozbek, Erman Cakal   +5 more
doaj   +1 more source

Use of Glucose‐Lowering Drugs for Type 2 Diabetes Among Danish Care Home Residents

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11086-11094, December 2026.
ABSTRACT Aims Care home admission often reflects frailty and limited life expectancy, potentially altering the benefit‐harm balance of glucose‐lowering drug (GLD) treatment for type 2 diabetes (T2D). Real‐world data on treatment patterns in this setting remain limited. We examined GLD use for T2D among Danish care home residents.
Hanin Harbi, Reimar W. Thomsen, Carina Lundby, Jacob Volmer Stidsen, Kurt Højlund, Jesper Ryg, Mette Reilev, Anton Pottegård   +7 more
wiley   +1 more source

Genotype‐Dependent Functional and Pharmacological Profiling of Rare GCK Variants Reveals Implications for Precision Management of Monogenic Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11821-11827, December 2026.
ABSTRACT Aims Rare GCK variants contribute to heterogeneous forms of monogenic diabetes, yet the molecular basis underlying their diverse functional consequences and pharmacological responsiveness remains incompletely understood. As glucokinase (GCK) serves as a central glucose sensor in pancreatic β‐cells and hepatocytes, defining the functional ...
Haoyu Bai, Jie Yu, Qiusha Zhu, Xue Zhou, Ting Xie, Tong Wang, Jing Ren, Chuhan Shao, Qian Zhang, Changhong Li, Xinhua Xiao   +10 more
wiley   +1 more source

Monogenic diabetes associated with PAX4 gene mutations (MODY9): first description in Russia

Сахарный диабет, 2017
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of disorders characterised by autosomal dominant type of inheritance and caused by genetic defects leading to dysfunction of pancreatic beta-cells. To date, at least 13 subtypes of MODY
Natalya A. Zubkova, Olesya A. Gioeva, Vasiliy M. Petrov, Evgeny V. Vasiliev, Alexei V. Timofeev, Anna V. Abrukova, Anatoly N. Tiulpakov   +6 more
doaj   +1 more source

Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1455-1463, December 2026.
ABSTRACT Introduction Pregnancy induces significant physiological changes in the hemostatic system, leading to a hypercoagulable state to prevent postpartum hemorrhage. These adaptations involve alterations in coagulation and fibrinolysis, which can be further modified in complicated pregnancies such as gestational diabetes mellitus (GDM) and ...
Yang Su, Yao Wei, Cheng Liu, Yafei Gao, Xiaolong Ma, Yongxin Li, Rui Qiao   +6 more
wiley   +1 more source

High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.

, 2011
OBJECTIVE: Maturity-onset diabetes of the young (MODY) as a result of mutations in hepatocyte nuclear factor 1-α (HNF1A) is often misdiagnosed as type 1 diabetes or type 2 diabetes.
Jane Lawry, Katharine R. Owen, Hattersley, Andrew T., Gloyn, A. L., Tim J. McDonald, Anna L. Gloyn, Lawry, J., Shields, Beverley, Sian Ellard, Owen, K., Beverley M. Shields, Ellard, Sian, Andrew T. Hattersley, McDonald, Timothy J.   +13 more
core   +1 more source

Evaluation of a secondary care multidisciplinary clinic for adults with early‐onset type 2 diabetes at high risk in Leicester, Leicestershire and Rutland

Diabetic Medicine, Volume 43, Issue 11, November 2026.
Abstract Background Clinical services for adults with early‐onset type 2 diabetes (EOT2D) are in urgent need of improvement. Methods We evaluated a multi‐disciplinary clinic for individuals with EOT2D at high risk (HbA1c >9%/triglyceride >20 mmol/L), providing 2–3 flexibly arranged consultations per individual between March 2024 and September 2025 ...
Jonathan Goldney, Malak Hamza, Priscilla Sarkar, Harriet Morgan, Nicole Green, James Ridgeway, Victoria Alabraba, Laura Willcocks, Krupali Chandracant, Kashmala Javed, Rhys O'Callaghan, Finley Turner, Samuel Seidu, Claire L. Meek, Melanie J. Davies   +14 more
wiley   +1 more source

An Italian MODY family with proband and son carrying variants in GCK and HFN1A: is it a true case of digenic MODY?

, 2023
Maturity Onset Diabetes of the Young (MODY) is a monogenic autosomal dominant disorder affecting 1-5 % of all patients with diabetes mellitus. In Caucasians, GCK and HNF1A mutations are the most common cause of MODY.
Bianchi, Cristina, Randazzo, Emioli, Lucchesi, Daniela, Del Prato, Stefano   +3 more
core   +1 more source

Genetic testing for glucokinase mutations in clinically selected patients with MODY: a worthwhile investment [PDF]

, 2005
The differential diagnosis for children with diabetes includes a group of monogenic diabetic disorders known as maturity-onset diabetes of the young (MODY). So far, six underlying gene defects have been identified.
Schnyder, Sabine, Flück, Christa E., Hattersley, Andrew T., Mullis, Primus E., Ellard, Sian   +4 more
core   +1 more source