Results 51 to 60 of about 23,263 (212)

Gene expression profiling of molecular target genes which are regulated by hepatocyte nuclear factor 1 Alpha (HNF1A) in rat insulin-secreting cells: role in HNF1A-MODY

, 2009
In this project, we were interested in studying HNF1A-induced defects in the expression of genes involved in the differentiation and regeneration of beta-cells in a cellular model of HNFlA-maturity-onset-diabetes-of-the-young(HNF1A-MODY), as well as the ...
Caroline Bonner (3124185)
core   +1 more source

MODY 증후군

, 2010
Maturity-onset diabetes of the young (MODY) is a heterogenous form of diabetes characterized by the early onset of diabetes, autosomal dominant inheritance, and impaired insulin secretion.
황, 진순
core   +1 more source

Screening of Mutations in Maturity-onset Diabetes of the Young-related Genes and RFX6 in Children with Autoantibody-negative Type 1 Diabetes Mellitus

JCRPE
INTRODUCTION: Maturity-onset diabetes of the young (MODY) is the most common type of monogenic diabetes. To date, mutations have been identified in 14 different genes of patients with a clinical diagnosis of MODY. This study screened mutations in 14 MODY-
Enver Şimşek, Oğuz Çilingir, Tülay Şimşek, Sinem Kocagil, Ebru Erzurumluoğlu Gökalp, Meliha Demiral, Çiğdem Binay   +6 more
doaj   +1 more source

Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY

Redox Biology, 2021
Glucokinase-maturity onset diabetes of the young (GCK-MODY) represents a rare genetic disorder due to mutation in the glucokinase (GCK) gene. The low incidence of vascular complications in GCK-MODY makes it a natural paradigm for interrogating molecular ...
Xiaojing Wang, Sin Man Lam, Mingjun Cao, Tong Wang, Zhixin Wang, Miao Yu, Bowen Li, Huabing Zhang, Fan Ping, Guangyao Song, Kai Feng, Qian Zhang, Jianping Xu, Liyuan Zhou, Mingqun Deng, Xiao Zhai, Xinhua Xiao, Guanghou Shui   +17 more
doaj   +1 more source

Embedding psychological care in diabetes services: Why it's time to innovate and integrate

Diabetic Medicine, EarlyView.
Abstract Aims This narrative review synthesizes current knowledge on the psychological dimensions of diabetes care, identifies gaps in evidence and practice and proposes innovative pathways for embedding psychological care into routine diabetes services.
Per Winterdijk, Henk‐Jan Aanstoot, Christine Fransman, Andreia Mocan, Giesje Nefs   +4 more
wiley   +1 more source

Clinical characteristics, treatment, and treatment switch after molecular‐genetic classification in individuals with maturity‐onset diabetes of the young: Insights from the multicenter real‐world DPV registry

Journal of Diabetes
Background Individuals with maturity‐onset diabetes of the young (MODY) are often misdiagnosed as type 1 or type 2 diabetes and receive inappropriate care. We aimed to investigate the characteristics and treatment of all MODY types in a multicenter, real‐
Stefanie Lanzinger, Katharina Laubner, Katharina Warncke, Julia K. Mader, Sebastian Kummer, Claudia Boettcher, Torben Biester, Angela Galler, Daniela Klose, Reinhard W. Holl   +9 more
doaj   +1 more source

Use of Glucose‐Lowering Drugs for Type 2 Diabetes Among Danish Care Home Residents

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Care home admission often reflects frailty and limited life expectancy, potentially altering the benefit‐harm balance of glucose‐lowering drug (GLD) treatment for type 2 diabetes (T2D). Real‐world data on treatment patterns in this setting remain limited. We examined GLD use for T2D among Danish care home residents.
Hanin Harbi, Reimar W. Thomsen, Carina Lundby, Jacob Volmer Stidsen, Kurt Højlund, Jesper Ryg, Mette Reilev, Anton Pottegård   +7 more
wiley   +1 more source

Digital platform strategies from an incumbent perspective: An exploration of contextual factors and connectors

European Management Review, EarlyView.
ABSTRACT Multi‐sided platform (MSP) models have become more relevant for incumbent companies, requiring them to develop MSP engagement strategies. This study sheds light on the complex process incumbents undergo in developing platform strategies. Adopting an inductive research design, we conducted interviews with 37 decision‐makers across 35 incumbent ...
Lukas Zechel, Vivek K. Velamuri
wiley   +1 more source

Hypoglycemic response to dorzagliatin in a patient with GCK-MODY

OBJECTIVEMetformin, insulin, and insulin secretagogues do not alter HbA1c levels in glucokinase-maturity-onset diabetes of the young (GCK-MODY). However, the efficacy of the new hypoglycemic drugs on GCK-MODY remains unclear.RESEARCH DESIGN AND METHODSWe
Tianhao Ba (14802617), Yumin Ma (9740452), Qian Ren (230930), Linong Ji (131708), Xueyao Han (319175), Yilin Zhao (487866)   +5 more
core   +1 more source

Study of homogenization on media milling time in preparation of irbesartan nanosuspension and optimization using design of experiments (DoE)

Future Journal of Pharmaceutical Sciences, 2020
Background The present investigation aimed at preparing nanosuspension of irbesartan to improve its dissolution. Dissolution enhancement of irbesartan can improve the oral bioavailability.
Chetan Borkhataria, Dhavalkumar Patel, Swati Bhagora, Nilesh Patel, Kalpesh Patel, Ravi Manek   +5 more
doaj   +1 more source