Results 71 to 80 of about 30,818 (335)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Communications Biology, 2022 AbstractLife underground has constrained the evolution of subterranean mammals to maximize digging performance. However, the mechanisms modulating morphological change and development of fossorial adaptations in such taxa are still poorly known. We assessed the morpho-functional diversity and early postnatal development of fossorial adaptations (bone ...
Germán Montoya-Sanhueza +5 more
openaire +4 more sources
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Nature CommunicationsThe naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease.
Chris G. Faulkes +10 more
doaj +1 more source
The real war on cancer: the evolutionary dynamics of cancer suppression. [PDF]
, 2012 Cancer is a disease of multicellular animals caused by unregulated cell division. The prevailing model of cancer (multistage carcinogenesis) is based on the view that cancer results after a series of (generally somatic) mutations that knock out the ...
Nunney, Leonard
core +1 more source
Advanced Engineering Materials, EarlyView.A numerical model resulting from irreversible thermodynamics for describing transport processes is introduced, focusing on thermodynamic activity gradients as the actual driving force for diffusion. Implemented in CUDA C++ and using CalPhaD methods for determining the necessary activity data, the model accurately simulates interdiffusion in aluminum ...
Ulrich Holländer +3 more
wiley +1 more source
Global Ecology and ConservationMonitoring rare or endangered species is vital for biodiversity conservation, but it is particularly challenging for hidden or elusive species. The subterranean Eurasian blind mole rats are such species. The newly identified endemic species of this group
Orsolya Moldován +6 more
doaj +1 more source
Circadian rhythms of locomotor activity in Ansell's mole‐rat: are mole‐rat's clocks ticking? [PDF]
Journal of Zoology, 2008 AbstractCircadian rhythms of locomotor activity have been investigated in several African mole‐rat species. Even though mole‐rats spend most of their lives in underground burrows devoid of light, studies have shown that they do possess circadian rhythms to some extent. We investigated the circadian rhythms of locomotor activity in 11 male Ansell's mole‐
De Vries, J.L. +3 more
openaire +2 more sources
The accelerating influence of humans on mammalian macroecological patterns over the late Quaternary [PDF]
, 2019 The transition of hominins to a largely meat-based diet ~1.8 million years ago led to the exploitation of other mammals for food and resources. As hominins, particularly archaic and modern humans, became increasingly abundant and dispersed across the ...
Elliott Smith, Rosemary E. +4 more
core +1 more source
Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always [PDF]
, 2017 Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle.
Carelli, Valerio +7 more
core +1 more source