Results 51 to 60 of about 30,818 (335)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Long-lived cancer-resistant rodents as new model species for cancer research
Frontiers in Genetics, 2013 Most rodents are small and short-lived, but several lineages have independently evolved long lifespans without a concomitant increase in body mass.
Jorge eAzpurua, Andrei eSeluanov
doaj +1 more source
Spalax denizliensis sp. nov. (Spalacidae, Rodentia) from an early Pleistocene-aged locality in the Denizli Basin (southwestern Turkey) [PDF]
, 2018 It is thought that Spalacidae (Rodentia, Mammalia) originated in Anatolia. They are widespread among Neogene-aged faunas in Anatolia and they are used as zonal fossils because of their strong evolutionary dynamics. Only one fossil species (S.
Erten, Hüseyin
core +2 more sources
The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat. [PDF]
, 2015 Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth factors (IGFs) have pluripotent
A Denley +46 more
core +10 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Redox Biology, 2016 Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models.
Maja Dziegelewska +13 more
doaj +1 more source
Communications Biology, 2021 Woei-Yaw Chee et al. explore the molecular mechanisms of β-catenin involvement in cholesterol metabolism suppressing cellular senescence in naked mole-rat cells.
Woei-Yaw Chee +9 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2022 Differences in individual locomotor activity patterns may be linked to a number of ecological factors, such as changes in ambient temperature or photoperiod.
Kyle T. Finn +5 more
doaj +1 more source
Onthophagus species (Coleoptera: Scarabaeidae) associated with the Hungarian lesser blind mole-rat (Nannospalax hungaricus) (Mammalia: Spalacidae) [PDF]
, 2014 Two rare species of Onthophagus Latreille, 1802 associated with subterranean rodents were found in a nature protection area where the Hungarian lesser blind mole-rat, Nannospalax hungaricus (Nehring, 1898) is also present.
Danyik, T., Deli, T., Merkl, O.
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source