Results 61 to 70 of about 30,818 (335)

Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

eLife, 2021
In some mammals and many social insects, highly cooperative societies are characterized by reproductive division of labor, in which breeders and nonbreeders become behaviorally and morphologically distinct.
Rachel A Johnston, Philippe Vullioud, Jack Thorley, Henry Kirveslahti, Leyao Shen, Sayan Mukherjee, Courtney M Karner, Tim Clutton-Brock, Jenny Tung   +8 more
doaj   +1 more source

Absence of CD59 in guinea pigs: Analysis of the Cavia porcellus genome suggests the evolution of a CD59 pseudogene [PDF]

, 2018
CD59 is a membrane-bound regulatory protein that inhibits the assembly of the terminal membrane attack complex (C5b-9) of complement. From its original discovery in humans almost 30 years ago, CD59 has been characterized in a variety of species, from ...
Boshra, Hani, Hughes, Timothy R., Morgan, B. Paul, Rodriguez de Cordoba, Santiago, Zelek, Wioleta M.   +4 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Comparative analysis of the primary structure and production of recombinant poly(ADP-ribose)polymerase 1 of long-lived Heterocephalus glaber

Вавиловский журнал генетики и селекции
DNA repair is a most important cellular process that helps maintain the integrity of the genome and is currently considered by researchers as one of the factors determining the maximum lifespan.
K. N. Naumenko, A. R. Nurislamov, K. D. Nazarov, V. S. Fishman, A. A. Popov, I. O. Petruseva, A. N. Evdokimov, O. I. Lavrik   +7 more
doaj   +1 more source

Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus. [PDF]

PLoS ONE, 2012
Naked mole-rats are highly social and strictly subterranean rodents that live in large communal colonies in sealed and chronically oxygen-depleted burrows.
Bethany L Peterson, John Larson, Rochelle Buffenstein, Thomas J Park, Christopher P Fall   +4 more
doaj   +1 more source

The Cost of Reproduction in a Cooperatively Breeding Mammal: Consequences of Seasonal Variation in Rainfall, Reproduction, and Reproductive Suppression

Frontiers in Physiology, 2021
Biological investments, such as reproduction, are influenced by both biotic and abiotic factors and their interactions. The trade-off between reproduction and survival has been well established.
Paul Juan Jacobs, Daniel William Hart, Tobias Suess, Andries Koch Janse van Vuuren, Nigel Charles Bennett   +4 more
doaj   +1 more source

Hypothesis of the basic biological sense of cancer revisited: a putative explanation of Peto's paradox [PDF]

, 2017
The conventional interpretation of cancer, summarized in the unified genetic theory of carcinogenesis, assumes that the malignant cell is the anatomical and physiological unit of cancer.
Bustuoabad, Oscar David, Ruggiero, Raul Alejandro   +1 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. [PDF]

PLoS ONE, 2012
The longest-lived rodent, the naked mole-rat (Bathyergidae; Heterocephalus glaber), maintains robust health for at least 75% of its 32 year lifespan, suggesting that the decline in genomic integrity or protein homeostasis routinely observed during aging,
Karl A Rodriguez, Yael H Edrey, Pawel Osmulski, Maria Gaczynska, Rochelle Buffenstein   +4 more
doaj   +1 more source

Old views and new insights: taxonomic revision of the Bukovina blind mole rat, Spalax graecus (Rodentia: Spalacinae) [PDF]

, 2013
As a result of their rather uniform external appearance and gross cranial morphology, the systematics of blind mole rats has been hotly debated over the last century; however, the separation of the large-bodied and small-bodied blind mole rats at the ...
Csorba, Gábor, Csorba, Máté, Farkas, János, Hadid, Yarin, Hegyeli, Zsolt, Homonnay, Zalán G., Krízsik, Virág, Németh, Attila, Pavlíček, Tomáš, Sugár, Szilárd   +9 more
core   +2 more sources